99Tcm-HL91与99Tcm-MIBI比较显像对甲状腺冷结节的诊断价值

目的：比较99Tcm-HL91和99Tcm-MIBI显像定性及半定量分析对甲状腺冷结节的诊断价值。方法：对103例99TcmO4-甲状腺扫描提示为冷结节的患者手术前行SPECT亲肿瘤显像，其中99Tcm-HL91显像组35例，99Tcm-MIBI显像组68例；并对两组患者早期和延迟图像的定性和半定量分析结果进行比较。结果：99Tcm-HL91乏氧显像对甲状腺冷结节诊断的准确度和特异度均高于99Tcm-MIBI亲肿瘤显像，差异有显著性（P<0.001）；两种显像方法的敏感度无显著差异。结论：99Tcm-HL91乏氧显像对甲状腺冷结节良恶性的鉴别诊断更具有优越性。

Diagnostic value of thyroid cold nodules by using 99Tcm-HL91/99Tcm-MIBI imaging

Objective：To evaluate the diagnostic value of ^99Tc^m-HL91 and ^99Tc^m-MIBI imaging in thyroid cold nodules with the qualitative and semi-quantitative analysis.Methods：103 patients with cold nodules underwent SPECT tumor imaging before operation.Thirty-five patients underwent 99Tcm-HL91 imaging,68 patients underwent ^99Tc^m-MIBI imaging;and then comparing the qualitative and semi-quantitative analysis of the early and delayed images in the two groups.Results：The accuracy and specificity of ^99Tc^m-HL91 hypoxia imaging in the diagnosis of thyroid cold nodules were higher than ^99Tc^m-MIBI tumor imaging,there was a significant difference（P〈0.001）;the sensitivity of the two imaging methods had no significant difference.Conclusion：^99Tc^m-HL91 imaging in differentiating malignant from benign thyroid cold nodules is more useful than ^99Tc^m-MIBI imaging.