| 盐酸吉西他滨壳聚糖纳米粒的制备及其体外释药特性研究 |
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| 引用本文： | 石士慧,潘卫东. 盐酸吉西他滨壳聚糖纳米粒的制备及其体外释药特性研究[J]. 中国新药杂志, 2011, 0(23) |
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| 作者姓名： | 石士慧 潘卫东 |
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| 作者单位： | 江苏省连云港市第二人民医院东院药剂科;江苏联合职业技术学院连云港中医药分院; |
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| 摘 要： | 目的:优化盐酸吉西他滨壳聚糖纳米粒的制备参数,考察纳米粒体外释药特性。方法:以壳聚糖为辅料,采用离子交联法制备盐酸吉西他滨壳聚糖纳米粒,以包封率、载药量、粒径为参考指标设计试验,确定优化制备参数,以透射电镜观察其表观特征,考察纳米粒体外释药程度。结果:以优化参数制备的盐酸吉西他滨壳聚糖纳米粒包封率为(78.93±1.52)%,载药量为(11.71±0.88)%,纳米粒的平均粒径为(169±24)nm,体外释放试验表明纳米粒中盐酸吉西他滨的释放过程符合Higuchi方程。结论:盐酸吉西他滨可以通过离子交联法制备壳聚糖纳米粒,其粒径、包封率、载药量可控,具有缓释效果。
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| 关 键 词： | 盐酸吉西他滨 壳聚糖 纳米粒 药物释放 |
Preparation and in vitro release characteristics of gemcitabine hydrochloride chitosan nanoparticles |
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| SHI Shi-hui,PAN Wei-dong. Preparation and in vitro release characteristics of gemcitabine hydrochloride chitosan nanoparticles[J]. Chinese Journal of New Drugs, 2011, 0(23) |
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| Authors: | SHI Shi-hui PAN Wei-dong |
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| Affiliation: | SHI Shi-hui1,PAN Wei-dong2(1 The Second People's Hospital of Lianyungang East Pharmacy,Lianyungang 222006,China,2 Jiangsu Joint Technology College Lianyungang Medicine Brance,China) |
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| Abstract: | Objective: To optimize the preparing method of gemcitabine hydrochloride chitosan nanoparticles(dFdC-CS-NPs),and investigate the in vitro release characteristics.Methods: The dFdC-CS-NPs were prepared using ionic gelation method with chitosan.The experiment method was designed based on evaluation of the mean particle size,the encapsulation efficiency and drug loading of dFdC-CS-NPs.The nanoparticles were observed by TEM,and the release curve was determined.Results: The nanoparticles observed by TEM were sph... |
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| Keywords: | gemcitabine hydrochloride chitosan nonoparticle drug release |
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