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正交设计优化伊曲康唑固体脂质纳米粒的处方组成与制备工艺
引用本文:苗蕾,杨春华,王金萍,黄桂华.正交设计优化伊曲康唑固体脂质纳米粒的处方组成与制备工艺[J].中国新药杂志,2011(23).
作者姓名:苗蕾  杨春华  王金萍  黄桂华
作者单位:山东大学药学院;
摘    要:目的:制备伊曲康唑固体脂质纳米粒(itraconazole solid lipid nanoparticles,ITZ-SLNs)并对其进行物相分析以确定纳米粒的形成。方法:以伊曲康唑(ITZ)为模型药物,硬脂酸为载体材料,采用乳化-低温固化法制备伊曲康唑固体脂质纳米粒(ITZ-SLN),正交试验设计优化处方组成和制备工艺,并对纳米粒的结构形态、粒径、表面电位、包封率、体外释药特性等进行了研究。结果:以优化处方制备的伊曲康唑固体脂质纳米粒为类球形实体,粒径分布比较均匀,平均粒径为dav=(118.2±15.00)nm,Zeta电位为-(37.06±0.53)mV,包封率为(92.11±1.60)%,药物体外释放符合Higuchi方程,经DSC分析证明纳米粒确已形成。结论:伊曲康唑固体脂质纳米粒有望成为新型缓释纳米给药系统。

关 键 词:伊曲康唑  固体脂质纳米粒  硬脂酸  乳化-低温固化法  

Orthogonal experiments optimizes the formulations and preparation conditions of itraconazole solid lipid nanoparticles
MIAO Lei,YANG Chun-hua,WANG Jin-ping,HUANG Gui-hua.Orthogonal experiments optimizes the formulations and preparation conditions of itraconazole solid lipid nanoparticles[J].Chinese Journal of New Drugs,2011(23).
Authors:MIAO Lei  YANG Chun-hua  WANG Jin-ping  HUANG Gui-hua
Institution:MIAO Lei,YANG Chun-hua,WANG Jin-ping,HUANG Gui-hua(College of Pharmacy,Shandong University,Jinan 250012,China)
Abstract:Objective: To prepare itraconazole solid lipid nanoparticles(ITZ-SLNs) and testify the formation of a new material phase by analysis of differential scanning calorimetry(DSC).Methods: TZ-SLNs were prepared by emulsification-low temperature solidification method with stearic acid as a carrier material.The formulations and the preparation conditions were optimized by orthogonal experiments using entrapment efficiency as evaluation index.The morphology was detected by transmission electron microscopy.The zeta ...
Keywords:itraconazole  solid lipid nanoparticles  stearic acid  emulsion low temperature solidification method  
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