| 大蒜辣素前体包芯片的制备 |
| |
| 引用本文： | 周圆,郑春丽,朱家壁.大蒜辣素前体包芯片的制备[J].中国新药杂志,2011(23). |
| |
| 作者姓名： | 周圆 郑春丽 朱家壁 |
| |
| 作者单位： | 中国药科大学药剂研究所; |
| |
| 基金项目： | 国家“重大新药创制”科技重大专项(2009ZX09310-004); 国家自然科学基金(30772663); 中央高校基本科研业务费专项(JKQ2009024) |
| |
| 摘 要： | 目的:制备大蒜辣素前体包芯片,使其口服后在短时间内促发酶促反应,生成大蒜辣素。方法:以蒜氨酸和蒜酶双层片为片芯,控酸颗粒为外层压制得到包芯片。并以人工胃液为介质小杯法考察包芯片大蒜辣素产率。结果:大蒜辣素前体包芯片在人工胃液中10 min内大蒜辣素产率>70%。结论:以蒜氨酸、蒜酶及控酸盐组合制备包芯片能够有效避免蒜酶在胃酸条件下失活,达到在体内获得较高产率大蒜辣素目的。
|
| 关 键 词： | 大蒜辣素 蒜氨酸 蒜酶 包芯片 人工胃液 |
Preparation of allicin prodrug package tablet |
| |
| ZHOU Yuan,ZHENG Chun-li,ZHU Jia-bi.Preparation of allicin prodrug package tablet[J].Chinese Journal of New Drugs,2011(23). |
| |
| Authors: | ZHOU Yuan ZHENG Chun-li ZHU Jia-bi |
| |
| Institution: | ZHOU Yuan,ZHENG Chun-li,ZHU Jia-bi(Pharmaceutical Research Institute,China Pharmaceutical University,Nanjing 210009,China) |
| |
| Abstract: | Objective: To prepare a package tablet that triggers enzymatic reaction in stomach producing allicin in a short time after oral administration.Methods: The immediate-release bilayer tablet core was prepared with alliin and alliinase.The package tablet was prepared with the core and the outer layer coat which can control acid.Small glass-method was adopted,and artifical gastric juice was used as the medium to determine the yield of the allicin.Results: In artificial gastric juice,the allicin yield of the pac... |
| |
| Keywords: | allicin alliin alliinase package tablet artificial gastric juice |
| 本文献已被 CNKI 等数据库收录！ |
