| 甘露聚糖肽对淋巴造血系统肿瘤支持治疗的临床荟萃研究 |
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| 引用本文： | 张朕华,吉蕊,郭月芳,盛雨辰,霍志军,梅其炳.甘露聚糖肽对淋巴造血系统肿瘤支持治疗的临床荟萃研究[J].中国新药杂志,2011(24). |
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| 作者姓名： | 张朕华 吉蕊 郭月芳 盛雨辰 霍志军 梅其炳 |
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| 作者单位： | 中国医药工业研究总院创新药物与制药工艺国家重点实验室;国家中医药管理局消化药理重点实验室; |
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| 基金项目： | 国家“重大新药创制”科技重大专项(2009ZX0901-007) |
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| 摘 要： | 目的:系统评价甘露聚糖肽对恶性非实体瘤支持治疗的有效性及安全性。方法:电子检索Co-chrane图书馆、MEDLINE,EMBASE,CNKI和CBM,纳入甘露聚糖肽治疗白血病、淋巴瘤、骨髓瘤的随机对照试验(RCT),检索日期至2011年10月。由两名研究者独立纳入试验、评价质量、提取数据并交叉核对。使用RevMan 5.0软件进行Meta分析。结果:纳入10项RCTs,共包括570例患者,其中治疗组300例,对照组270例。结果显示甘露聚糖肽可显著提高化疗的总有效率OR=3.9,95%CI:(2.45,6.20),Z=5.75,P<0.01;]显著提高T细胞免疫功能,分别为SMD=1.05,95%CI:(0.78,1.32);Z=7.55,P<0.01],SMD=1.38,95%CI:(0.64,2.13),Z=3.63,P<0.01],SMD=0.79,95%CI:(0.43,1.14),Z=4.35,P<0.01];改善肿瘤患者体力状况SMD=2.34,95%CI:(1.96,2.72),Z=12.09,P<0.01;]同时能显著降低各种化疗引起的毒副反应,如白细胞下降SMD=0.84,95...
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| 关 键 词： | 淋巴造血系统肿瘤 甘露聚糖肽 循证研究 |
Systematic review of mannatide injection in the treatment of lymphohaemopoietic tumors |
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| ZHANG Zhen-hua,JI Rui,GUO Yue-fang,SHENG Yu-chen,HUO Zhi-jun,MEI Qi-bing.Systematic review of mannatide injection in the treatment of lymphohaemopoietic tumors[J].Chinese Journal of New Drugs,2011(24). |
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| Authors: | ZHANG Zhen-hua JI Rui GUO Yue-fang SHENG Yu-chen HUO Zhi-jun MEI Qi-bing |
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| Institution: | ZHANG Zhen-hua1,JI Rui1,GUO Yue-fang1,SHENG Yu-chen1,HUO Zhi-jun1,MEI Qi-bing2(1 Key Laboratory of Rational Drug and Pharmaceutical Technology,China Institute of Pharmaceutical Industry,Shanghai 200040,China,2 Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine,Xi'an 710043,China) |
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| Abstract: | Objective: To evaluate the efficacy and safety of mannatide injection in the treatment of lymphohaemopoietic tumors.Methods: Literature was retrieved from Medline,EMBASE,Cochrane Library,CBM,VIP,and CNKI databases by computer and from relevant Chinese medical journals manually.Trial selection,quality evaluation and information extraction were performed according to including and excluding criteria.Meta analysis was conducted using RevMan 5.0 software.Results: Totally 10 RCTs and 570 patients(treatment group... |
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| Keywords: | lymphohaemopoietic tumor mannatide injection evidence-based medicine |
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