| 静脉滴注盐酸卡屈沙星注射液的健康人体药动学研究 |
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| 引用本文： | 王源园,张静,张登山,邹颖,刘广余. 静脉滴注盐酸卡屈沙星注射液的健康人体药动学研究[J]. 中国新药杂志, 2011, 0(23) |
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| 作者姓名： | 王源园 张静 张登山 邹颖 刘广余 |
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| 作者单位： | 南京医科大学第一附属医院药剂科;江苏省中医院药剂科; |
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| 摘 要： | 目的:研究静脉滴注盐酸卡屈沙星葡萄糖注射液在健康人体内的药动学。方法:20名健康成年志愿者随机分成两组,每组10人,男女各半,分别静滴盐酸卡屈沙星葡萄糖注射液0.3和0.4 g后,采用HPLC法测定血药浓度,使用DAS软件求出药动学参数。结果:两组的最大血药浓度(Cmax)分别为(5.2±0.6)和(7.3±1.7)μg.mL-1;消除半衰期(t1/2z)分别为(6.4±1.4)和(6.3±1.4)h;表观分布容积(Vz)分别为(90.9±22.7)和(83.4±21.3)L;清除率(CL)分别为(9.8±1.6)和(9.3±1.7)L.h-1;药时曲线下面积(AUC0～24)分别为(30.5±5.2)和(42.2±8.2)μg.h.mL-1。结论:t1/2z,Vz和CL经统计学检验,两组间无显著性差异,Cmax和AUC0～24与给药剂量呈正比。
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| 关 键 词： | 盐酸卡屈沙星 高效液相色谱法 药动学 |
Pharmacokinetics of caderofloxacin hydrochloride after intravenous infusion in healthy volunteers |
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| WANG Yuan-yuan,ZHANG Jing,ZHANG Deng-shan,ZOU Ying,LIU Guang-yu. Pharmacokinetics of caderofloxacin hydrochloride after intravenous infusion in healthy volunteers[J]. Chinese Journal of New Drugs, 2011, 0(23) |
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| Authors: | WANG Yuan-yuan ZHANG Jing ZHANG Deng-shan ZOU Ying LIU Guang-yu |
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| Affiliation: | WANG Yuan-yuan1,ZHANG Jing1,ZHANG Deng-shan2,ZOU Ying1,LIU Guang-yu1(1 Department of Pharmacy,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China,2 Department of Pharmacy,Jiangsu Province Hospital of TCM,China) |
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| Abstract: | Objective: To investigate the pharmacokinetics of caderofloxacin hydrochloride after intravenous infusion in glucose injections in Chinese healthy volunteers.Methods: Totally 20 healthy volunteers were divided into two groups,10 volunteers(5 men and 5 women) per group.Volunteers in each group were intravenously infused with 0.3 g or 0.4 g caderofloxacin hydrochloride in glucose injection,respectively.The plasma concentrations were determined by HPLC method.The pharmacokinetic parameters were calculated by D... |
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| Keywords: | caderofloxacin hydrochloride HPLC pharmacokinetics |
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