| 质子泵抑制剂与急性间质性肾炎 |
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| 引用本文： | 雷招宝,柳青.质子泵抑制剂与急性间质性肾炎[J].中国新药杂志,2011(4):325-328,338. |
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| 作者姓名： | 雷招宝 柳青 |
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| 作者单位： | 丰城市人民医院;萍乡市第二人民医院药剂科; |
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| 摘 要： | 质子泵抑制剂(proton pump inhibitors,PPIs)致急性间质性肾炎(acute interstitial nephritis,AIN)是一种罕见而严重的药物不良事件.目前临床使用的PPIs如奥美拉唑、埃索美拉唑、泮托拉唑、雷贝拉唑和兰索拉唑都可致AIN,其中以奥美拉唑报道最多.PPIs致AIN的临床...
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| 关 键 词： | 质子泵抑制剂 急性间质性肾炎 药源性疾病 |
Proton pump inhibitors and acute interstitial nephritis |
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| LEI Zhao-bao,LIU Qing.Proton pump inhibitors and acute interstitial nephritis[J].Chinese Journal of New Drugs,2011(4):325-328,338. |
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| Authors: | LEI Zhao-bao LIU Qing |
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| Institution: | LEI Zhao-bao1,LIU Qing2(1 Fengcheng People's Hospital,Fengcheng 331100,China,2 Department of Pharmacy of PingxiangSecond People's Hospital,Pingxiang 337000,China) |
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| Abstract: | Acute interstitial nephritis(AIN) induced by proton pump inhibitors(PPIs) is a rare but serious adverse drug event.All PPIs,such as omeprazole,esomeprazole,pantoprazole,rabeprazole and lansoprazole,can cause AIN,but omeprazole-induced AIN is reported most frequently.The clinical manifestations of AIN induced by PPIs are atypical.It is difficult for the clinicians to make a correct diagnosis of AIN in time.Misdiagnosis and missed diagnosis occurred easily.The initial diagnosis can be made according to follow... |
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| Keywords: | proton pump inhibitor(PPIs) acute interstitial nephritis(AIN) drug-induced diseases |
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