| 热毒宁注射液的稳定性及与头孢菌素类药物的配伍研究 |
| |
| 引用本文： | 任亮,马菲,张印坡. 热毒宁注射液的稳定性及与头孢菌素类药物的配伍研究[J]. 中国新药杂志, 2011, 0(9) |
| |
| 作者姓名： | 任亮 马菲 张印坡 |
| |
| 作者单位： | 漯河医学高等专科学校;漯河市源汇区妇幼保健院; |
| |
| 摘 要： | 目的:观察热毒宁注射液在不同溶媒中的稳定性及与头孢菌素类药物的配伍情况。方法:用光阻法测定热毒宁注射液在5种注射液中的不溶性微粒情况。采用高效液相色谱法测定热毒宁注射液分别与5%葡萄糖注射液及0.9%氯化钠注射液配伍放置8 h内,配伍液中栀子苷含量的变化,并比较配伍前后pH值的变化。模拟临床条件观察头孢唑林、头孢呋辛、头孢曲松、头孢哌酮与热毒宁注射液配伍后不溶性微粒的情况。结果:热毒宁注射液与上述5种输液配伍后,微粒数均有所增加,其中与5%葡萄糖注射液、0.9%氯化钠注射液配伍后pH值和栀子苷含量均无显著性变化。热毒宁注射液与上述头孢菌素类药物配伍后均有可见物生成。结论:热毒宁注射液在临床输液中应注意不溶性微粒情况。热毒宁与头孢菌素类药物存在配伍禁忌。
|
| 关 键 词： | 热毒宁注射液 不溶性微粒 头孢菌素类 配伍 |
Stability of Reduning injection and its compatibility with cephalosporins |
| |
| REN Liang,MA Fei,ZHANG Yin-po. Stability of Reduning injection and its compatibility with cephalosporins[J]. Chinese Journal of New Drugs, 2011, 0(9) |
| |
| Authors: | REN Liang MA Fei ZHANG Yin-po |
| |
| Affiliation: | REN Liang1,MA Fei2,ZHANG Yin-po1(1 Luohe Medical College,Luohe 462000,China,2 Luohe Yuanhui District Maternal and Child Health Hospital,China) |
| |
| Abstract: | Objective:To investigate the stability of Reduning injection in different infusion solutions and its compatibility with cephalosporins.Methods:The insoluble particles of Reduning injection in five kinds of infusion solution were detected respectively by light-blockage method.The contents of geniposide in the solution mixed with 5% GS or 0.9 NS within 8 h were determined by HPLC.The appearance and pH value of the mixtures were compared with those before mixing.The changes after Reduning injection mixed with ... |
| |
| Keywords: | Reduning injection insoluble particle cephalosporins compatibility |
| 本文献已被 CNKI 等数据库收录！ |
|
