| 神经干细胞抗帕金森病的实验治疗学进展 |
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| 引用本文： | 孙懿,蒲小平.神经干细胞抗帕金森病的实验治疗学进展[J].中国新药杂志,2011(4):315-319. |
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| 作者姓名： | 孙懿 蒲小平 |
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| 作者单位： | 北京大学天然药物与仿生药物国家重点实验室;北京大学药学院分子与细胞药理学系; |
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| 基金项目： | 教育部博士点基金(20090001110069) |
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| 摘 要： | 神经干细胞(neural stem cells,NSCs)具有高度的自我更新能力、多向分化潜能(包括神经元、星型胶质细胞和少突胶质细胞)和迁移能力.主要来源于哺乳动物胚胎期的大部分脑区以及成体脑组织的两个区域:海马齿状回的颗粒下层和侧脑室的室管膜下区.目前,应用NSCs治疗帕金森病(Parkinson's diseas...
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| 关 键 词： | 神经干细胞 帕金森病 移植 诱导 神经再生 |
Progress in therapeutic use of neural stem cell in experimental treatment of Parkinson's disease |
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| SUN Yi,PU Xiao-ping.Progress in therapeutic use of neural stem cell in experimental treatment of Parkinson's disease[J].Chinese Journal of New Drugs,2011(4):315-319. |
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| Authors: | SUN Yi PU Xiao-ping |
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| Institution: | SUN Yi1,2,PU Xiao-ping1,2(1 State Key Laboratory of Natural and Biomimetic Drugs,2 Department of Molecular and Cellular Pharmacology,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China) |
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| Abstract: | Neural stem cells(NSCs) is one specific type of multipotential stem cells that have the ability to proliferate for a long time,to differentiate into multiple lineages,including neurons,astrocytes and oligodendrocytes,and to migrate toward damaged sites.In all mammalian species,these NSCs mainly exist in most regions of embryonic brain and at least two regions of the adult brain,the subgranular zone(SGZ) of the hippocampal dentate gyrus,and the subventricular zone(SVZ) of the lateral ventricle wall.Because o... |
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| Keywords: | neural stem cells Parkinson's disease transplantation induce neurogenesis |
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