| CYP2C9和CYP2C19基因多态性对健康中国人口服氯吡格雷后药效动力学的影响 |
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| 引用本文： | 蒋娟娟,田蕾,韩璐璐,严岩,黄一玲,刘红,谢爽,李一石. CYP2C9和CYP2C19基因多态性对健康中国人口服氯吡格雷后药效动力学的影响[J]. 中国新药杂志, 2011, 0(13) |
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| 作者姓名： | 蒋娟娟 田蕾 韩璐璐 严岩 黄一玲 刘红 谢爽 李一石 |
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| 作者单位： | 中国医学科学院北京协和医学院阜外心血管病医院卫生部心血管药物临床研究重点实验室; |
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| 基金项目： | 国家“重大新药创制”科技重大专项“创新药物临床研究技术平台建设”(2008ZX09312-018) |
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| 摘 要： | 目的:研究细胞色素代谢酶CYP2C9和CYP2C19基因多态性对中国健康人口服氯吡格雷后药效动力学的影响。方法:24例健康男性受试者单剂量空腹口服氯吡格雷150 mg。用TaqMan探针方法进行CYP2C9和CYP2C19基因分型。测定药前和药后2,5,10,24和48 h血小板聚集率。结果:24例健康受试者空腹口服氯吡格雷150 mg后2 h即观察到血小板聚集率的下降,药效持续至药后48 h。Emax[MPA相对于基线的降低的百分比(IPA)的最大值]在CYP2C19*1/*1,*1/*2(or*3),*2/*3(or*2)携带者中分别为(60.3±21.0),(48.3±13.4)和(29.9±13.8),有显著性差异(P<0.05)。Emax在CYP2C9*1/*1,*1/*2(or*3)携带者中分别为(44.9±52.2)和(50.8±29.4),没有显著性差异。AUEC(IPA-时间曲线下面积)在CYP2C19*1/*1,*1/*2(or*3),*2/*3(or*2)携带者中分别为(22.8±9.8),(20.0±6.6)和(9.51±9.7),在CYP2C9*1/*1,*1/*2(or*3)携带者...
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| 关 键 词： | 氯吡格雷 药效学 血小板聚集 CYP2C9 CYP2C19 |
Effects of CYP2C19 and CYP2C9 polymorphisms on the pharmacodynamics of clopidogrel in healthy Chinese |
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| JIANG Juan-juan,TIAN Lei,HAN Lu-lu,YAN Yan,HUANG Yi-ling,LIU Hong,XIE Shuang,LI Yi-shi. Effects of CYP2C19 and CYP2C9 polymorphisms on the pharmacodynamics of clopidogrel in healthy Chinese[J]. Chinese Journal of New Drugs, 2011, 0(13) |
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| Authors: | JIANG Juan-juan TIAN Lei HAN Lu-lu YAN Yan HUANG Yi-ling LIU Hong XIE Shuang LI Yi-shi |
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| Affiliation: | JIANG Juan-juan,TIAN Lei,HAN Lu-lu,YAN Yan,HUANG Yi-ling,LIU Hong,XIE Shuang,LI Yi-shi(Key Laboratory of Clinical Trial Research in Cardiovascular Drugs Ministry of Health,Cardiovascular Institute and Fuwai Hospital,Peking Union Medical College and Chinese Academy of Medical Science,Beijing 100037,China) |
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| Abstract: | Objective:To investigate the effects of CYP2C19 and CYP2C9 polymorphisms on the pharmacodynamics of clopidogrel in Chinese male healthy volunteers.Methods:Male volunteers(n=24) aged from 18 to 35 were orally administrated with clopidogrel tablet 150mg.Genotyping was performed for CYP2C19 and CYP2C9 on samples from healthy subjects participating in the study.Platelet aggregation was measured before and 2,5,10,24,48h after administration.Results:Antiplatelet effect was observed 2h after administration,and mai... |
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| Keywords: | clopidogrel pharmacodynamics platelet aggregation CYP2C9 CYP2C19 |
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