| 戊二酰亚胺类抗生素S632最新研究进展 |
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| 引用本文： | 邓洪斌,李电东,蔡年生. 戊二酰亚胺类抗生素S632最新研究进展[J]. 中国新药杂志, 2011, 0(23) |
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| 作者姓名： | 邓洪斌 李电东 蔡年生 |
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| 作者单位： | 中国医学科学院北京协和医学院医药生物技术研究所; |
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| 基金项目： | 国家自然科学基金(81072645) |
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| 摘 要： | 戊二酰亚胺类抗生素是由链霉菌产生的一类结构中含有酰亚胺环、具有多种生物学活性的微生物产物。近年来发现戊二酰亚胺类新抗生素S632具有显著的抗病毒、抗肿瘤、保护神经元等多种生物学活性,表明该类抗生素具有重要的理论研究价值和开发应用前景。文中从以下几个方面综述了抗生素S632的最新研究现状及进展,包括分子结构与理化性质、含量测定方法及内控质量标准、多种生物学活性(抗病毒、抗肿瘤、神经元保护作用、炎症反应的抑制作用),同时对S632的构效关系及其作用机制也进行了探讨。
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| 关 键 词： | 戊二酰亚胺类抗生素 S632 生物学活性 |
New progress in research of the glutarimide antibiotics S632 |
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| DENG Hong-bin,LI Dian-dong,CAI Nian-sheng. New progress in research of the glutarimide antibiotics S632[J]. Chinese Journal of New Drugs, 2011, 0(23) |
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| Authors: | DENG Hong-bin LI Dian-dong CAI Nian-sheng |
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| Affiliation: | DENG Hong-bin,LI Dian-dong,CAI Nian-sheng(Insititute of Medicinal Biotechnology,Chinese Academy of Medical Sciences & Peking Union Medical Collegy,Beijing 100050,China) |
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| Abstract: | Glutarimide antibiotics are a class of glutarimide-containing micobial products derived from Streptomyces fermentations with multiplicate biological activities.Recent studies showed that S632,a new member of the glutarimide antibiotics,has an important prospect of development and utilization in antiviral,antitumor and immunosuppressive therapies.Thus,we reviewed the structure,physical and chemical properties and biological activities,such as antiviral and antitumor effects,protective effect on neurons and a... |
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| Keywords: | glutarimide antibiotics S632 biological activity |
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