| 动态心电图评价依帕司他对糖尿病心率变异性影响和疗效分析 |
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| 引用本文： | 林令华,李志改,于军会,许金华,孟凡霞.动态心电图评价依帕司他对糖尿病心率变异性影响和疗效分析[J].中国新药杂志,2011(21). |
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| 作者姓名： | 林令华 李志改 于军会 许金华 孟凡霞 |
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| 作者单位： | 江苏省东海县人民医院药剂科; |
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| 基金项目： | 江苏省卫生厅临床药学科研课题项目(P200412) |
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| 摘 要： | 目的:应用动态心电图评价依帕司他对糖尿病患者心率变异性的影响,确认依帕司他治疗糖尿病心脏自主神经病变的疗效。方法:收集糖尿病合并心脏自主神经病变患者100例,分为治疗组和对照组,治疗组患者口服依帕司他50 mg,tid,共8周。运用24 h动态心电图检测所有患者在治疗前后心率变异性指标的变化,观察依帕司他治疗糖尿病心脏自主神经病变的疗效。结果:治疗组心率变异性各项指标治疗2个疗程后较治疗前有显著提高,自主神经症状明显好转,与对照组比较有显著意义。结论:依帕司他治疗糖尿病心脏自主神经病变的疗效显著,可改善患者心率变异性。
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| 关 键 词： | 依帕司他 糖尿病 心脏自主神经病变 心率变异性 动态心电图 |
Effect of epalrestat on heart rate variability in diabetic patients |
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| LIN Ling-hua,LI Zhi-gai,YU Jun-hui,XU Jin-hua,MENG Fan-xia.Effect of epalrestat on heart rate variability in diabetic patients[J].Chinese Journal of New Drugs,2011(21). |
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| Authors: | LIN Ling-hua LI Zhi-gai YU Jun-hui XU Jin-hua MENG Fan-xia |
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| Institution: | LIN Ling-hua,LI Zhi-gai,YU Jun-hui,XU Jin-hua,MENG Fan-xia(Donghai People's Hospital of Jiangsu Province,Lianyungang 222300,China) |
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| Abstract: | Objective: To evaluate the effect of epalrestat on heart rate variability in diabetic patients.Methods: Totally 100 diabetic patients with cardiac autonmic neuropathy were analyzed.The patients were treated with 50mg epalrestat,3 times a day for 8 weeks.The heart rate variability(HRV) in all patients was monitored with a 24-h holter.Results: The indexes of HRV were significant improved after 8-week treatment.Conclusion: Epalrestat can improve HRV in diabetic patients,and it is an effective treatment of card... |
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| Keywords: | epalrestat diabetes cardiac autonmic neuropathy heart rate variability 24h holter |
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