| 复方奥硝唑大黄口腔膜对大鼠实验性口腔溃疡的治疗作用 |
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| 引用本文： | 范春玲,王玉洁,杨华,丁晓霞,贺殿.复方奥硝唑大黄口腔膜对大鼠实验性口腔溃疡的治疗作用[J].中国新药杂志,2011(12). |
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| 作者姓名： | 范春玲 王玉洁 杨华 丁晓霞 贺殿 |
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| 作者单位： | 甘肃省肿瘤医院药剂科;兰州大学药学院药物化学研究所; |
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| 摘 要： | 目的:观察复方奥硝唑大黄口腔膜对Wistar大鼠实验性口腔溃疡的治疗作用。方法:建立Wistar大鼠口腔溃疡动物模型,将模型动物随机分成5组:复方奥硝唑大黄口腔膜高、中、低剂量组、奥硝唑膜阳性对照组和模型对照组,观察给药后溃疡面的愈合情况。结果:各剂量复方奥硝唑大黄口腔膜均能不同程度减小溃疡面直径。结论:复方奥硝唑大黄口腔膜对Wistar大鼠实验性口腔溃疡有较好的治疗作用。
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| 关 键 词： | 复方奥硝唑大黄口腔膜 口腔溃疡 治疗作用 |
Effect of compound ornidazole-rhubarb buccal film on oral ulcer in rats |
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| FAN Chun-ling,WANG Yu-jie,YANG Hua,DING Xiao-xia,HE Dian.Effect of compound ornidazole-rhubarb buccal film on oral ulcer in rats[J].Chinese Journal of New Drugs,2011(12). |
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| Authors: | FAN Chun-ling WANG Yu-jie YANG Hua DING Xiao-xia HE Dian |
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| Institution: | FAN Chun-ling1,WANG Yu-jie1,YANG Hua1,DING Xiao-xia1,HE Dian2(1 Department of Pharmacy,The Gansu Province Tumor Hospital,Lanzhou 730050,China,2 Institute of Medicinal Chemistry,School of Pharmacy,Lanzhou University,Lanzhou 730000,China) |
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| Abstract: | Objective: To evaluate the effect of compound ornidazole-rhubarb buccal film on oral ulcer in Wistar rats.Methods: A model of ulcer in the oral mucosa was induced in Wistar rats.The rats were treated with 3 doses of compound ornidazole-rhubarb buccal film,or ornidazole film.The changes in ulcer recovery were monitored after treatment.Results: Various doses of compound ornidazole-rhubarb buccal film significantly shrank the ulcer areas at different degrees.Conclusion: Compound ornidazole-rhubarb buccal film ... |
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| Keywords: | compound ornidazole-rhubarb buccal film oral ulcer therapeutic effect |
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