| 乳糖化-去甲斑蝥素磷脂复合物及其pH敏感型脂质体的制备 |
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| 引用本文： | 周奕,许静玉,管敏,张学农. 乳糖化-去甲斑蝥素磷脂复合物及其pH敏感型脂质体的制备[J]. 中国新药杂志, 2011, 0(17) |
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| 作者姓名： | 周奕 许静玉 管敏 张学农 |
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| 作者单位： | 苏州大学药学院药剂学教研室; |
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| 基金项目： | 国家“重大新药创制”科技重大专项(2009ZX09310-001); 国家科技重大技术研究项目(973)(2009CB930300); 国家科技支撑计划(2006BAI09B00); 江苏省卫生厅项目(H200630); 江苏省“六大人才高峰”资助项目 |
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| 摘 要： | 目的:合成乳糖化-去甲斑蝥素磷脂复合物,并制备其pH敏感型脂质体。方法:将乳糖化-去甲斑蝥素与磷脂聚合成药物磷脂复合物,并采用FT-IR、DSC和1H-NMR对其进行表征。逆向蒸发法制备药物磷脂复合物脂质体;利用羧甲基壳聚糖与脂质体表面的静电吸附作用,使羧甲基壳聚糖吸附在脂质体表面,制备乳糖化-去甲斑蝥素磷脂复合物pH敏感型脂质体;考察了药物与磷脂的复合率,磷脂复合物脂质体的包封率,粒径大小和分布,以及体外释药特性。结果:药物磷脂复合率为(97.2±2.01)%,磷脂复合物脂质体的平均包封率为(70.00±1.30)%,平均粒径为(47.18±4.16)nm,粒径跨距为(0.70±0.07),电镜显示其形态圆整,体外释药符合Weibull方程。结论:乳糖化-去甲斑蝥素磷脂复合率高,制成的pH敏感型脂质体性质稳定,且具有缓释特性。
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| 关 键 词： | 乳糖化-去甲斑蝥素 磷脂复合物 pH敏感型脂质体 体外释放 |
Preparation of lactosyl-norcantharitin phospholipid complex and its pH-sensitive liposomes |
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| ZHOU Yi,XU Jing-yu,GUAN Min,ZAHNG Xue-nong. Preparation of lactosyl-norcantharitin phospholipid complex and its pH-sensitive liposomes[J]. Chinese Journal of New Drugs, 2011, 0(17) |
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| Authors: | ZHOU Yi XU Jing-yu GUAN Min ZAHNG Xue-nong |
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| Affiliation: | ZHOU Yi,XU Jing-yu,GUAN Min,ZAHNG Xue-nong(Department of Pharmaceutics,School of Pharmacy,Soochow University,Suzhou 215123,China) |
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| Abstract: | Objective: To prepare lactosyl-norcantharitin(Lac-NCTD) phospholipid complex and its pH-sensitive liposomes.Methods: Lac-NCTD phospholipid complex was prepared using solvent-evaporation,and its correlated physicochemical properties were confirmed with solubility test,FT-IR,DSC and 1H-NMR.The phospholipid complex liposomes were prepared by the reverse phase evaporation method,and then pH-sensitive liposomes of Lac-NCTD phospholipid complex were obtained with the carboxymethyl chitosan(CMCT) absorbed on the s... |
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| Keywords: | lactosyl-norcantharidin phospholipid complex pH-sensitive liposomes in vitro release |
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