| 复方丹参滴丸在慢性移植肾肾病中的应用研究 |
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| 引用本文： | 陈益荣,王平贤,黄赤兵,范明齐,冯嘉瑜,肖亚,高渝,张嘉希. 复方丹参滴丸在慢性移植肾肾病中的应用研究[J]. 中国新药杂志, 2011, 0(15) |
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| 作者姓名： | 陈益荣 王平贤 黄赤兵 范明齐 冯嘉瑜 肖亚 高渝 张嘉希 |
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| 作者单位： | 第三军医大学第二附属医院泌尿外科; |
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| 摘 要： | 目的:探讨复方丹参滴丸能否改善慢性移植肾肾病(chronic allograft nephropathy,CAN)患者的肾功能。方法:选择我院2005年1月-2008年12月的肾移植术后、经活检明确诊断为CAN(Ⅰ～Ⅱ级)患者66例为研究对象,随机分为治疗组(A组,n=34),对照组(B组,n=32),A组患者常规抗慢性排斥治疗基础上加用复方丹参滴丸(剂量27 mg/丸,10丸/次,tid);B组维持原常规抗慢性排斥治疗方案不变。对患者的SCr,BUN,CCr,24 h尿总蛋白(24 h Upro)进行动态观察,入组时上述指标连查3次(间隔3 d),取平均值,以后每2周查1次,实验结束时再对上述指标连查3次(间隔3 d),取平均值,共观察6个月。结果:治疗前两组各指标无显著差异(P>0.05);服用复方丹参滴丸治疗6个月后,A组的SCr,BUN,CCr,24 h尿总蛋白(24 h Upro)均有显著改善(P<0.05),而B组各指标与治疗前比较无显著差异(P>0.05)。治疗6个月后,A组中肾功能好转19例,稳定11例,恶化4例;B组中肾功能好转8例,稳定12例,恶化12例,两组比较差异有显著性(P<0.05...
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| 关 键 词： | 慢性移植肾肾病 复方丹参滴丸 肾移植 |
Effect of compound Danshen drop pills on the treatment of chronic allograft nephropathy |
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| CHEN Yi-rong,WANG Ping-xian,HUANG Chi-bing,FAN Ming-qi,FENG Jia-yu,XIAO Ya,GAO Yu,ZHANG Jia-xi. Effect of compound Danshen drop pills on the treatment of chronic allograft nephropathy[J]. Chinese Journal of New Drugs, 2011, 0(15) |
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| Authors: | CHEN Yi-rong WANG Ping-xian HUANG Chi-bing FAN Ming-qi FENG Jia-yu XIAO Ya GAO Yu ZHANG Jia-xi |
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| Affiliation: | CHEN Yi-rong,WANG Ping-xian,HUANG Chi-bing,FAN Ming-qi,FENG Jia-yu,XIAO Ya,GAO Yu,ZHANG Jia-xi(Department of Urology,The Second Affiliated Hospital,Third Military Medical University,Chongqing 400037,China) |
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| Abstract: | Objective:To investigate the efficacy of compound Danshen drop pills(CDDP) for improving the renal function of patients with chronic allograft nephropathy(CAN).Methods:From January 1,2005 to December 31,2008,66 renal recipients with clinical diagnosis of CAN were enrolled and randomly divided into two groups.Patients in group A(n=34) were treated with immunosuppressive agents and CDDP(27mg/pill,270mg tid).Patients in group B(n=32) were treated with traditional immunosuppressive drugs.SCr,BUN,CCr,and urinary... |
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| Keywords: | chronic allograft nephropathy(CAN) compound Danshen drop pills renal transplantation |
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