| 复尔康注射液对人肝癌细胞株及裸鼠移植瘤的抑制作用 |
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| 引用本文： | 刘明华,章卓,任美萍,李蓉,冯文宇,肖顺汉.复尔康注射液对人肝癌细胞株及裸鼠移植瘤的抑制作用[J].中国新药杂志,2011(12). |
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| 作者姓名： | 刘明华 章卓 任美萍 李蓉 冯文宇 肖顺汉 |
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| 作者单位： | 泸州医学院药理学教研室;泸州医学院药物研究所; |
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| 基金项目： | 四川省科技厅支撑计划(2008SG0036) |
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| 摘 要： | 目的:研究复尔康注射液对人肝癌细胞株增殖及裸鼠移植瘤生长的影响。方法:采用CCK8试剂盒检测复尔康注射液对人肝癌细胞株SMMC-7721和BeL-7402增殖的抑制作用;建立SMMC-7721细胞裸鼠移植瘤模型,通过比较肿瘤体积(tumor volume,TV)、相对肿瘤体积(relative tumor volume,RTV)和相对肿瘤增殖率(T/C)考察复尔康注射液对肿瘤生长的影响。结果:复尔康注射液对SMMC-7721和BeL-7402的IC50分别为(61.51±1.58),(68.39±7.16)mg·L-1;不同剂量复尔康注射液能够不同程度地抑制裸鼠移植瘤的生长,与阴性对照组比较,P<0.05。低、中、高剂量复尔康注射液组(0.065,0.130,0.260 g·kg-1)T/C分别为57.75%,39.9%和44.08%。结论:复尔康注射液体外能抑制人肝癌细胞株的增殖,体内能明显抑制SMMC-7721细胞裸鼠移植瘤的生长。
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| 关 键 词： | 复尔康注射液 人肝癌细胞株 裸鼠 |
Inhibitory effect of Fu-er-kang injection on hepatocellular carcinoma cells and tumor xenograft in nude mice |
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| LIU Ming-hua,ZHANG Zhuo,REN Mei-ping,LI Rong,FENG Wen-yu,XIAO Shun-han.Inhibitory effect of Fu-er-kang injection on hepatocellular carcinoma cells and tumor xenograft in nude mice[J].Chinese Journal of New Drugs,2011(12). |
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| Authors: | LIU Ming-hua ZHANG Zhuo REN Mei-ping LI Rong FENG Wen-yu XIAO Shun-han |
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| Institution: | LIU Ming-hua1,ZHANG Zhuo1,REN Mei-ping1,LI Rong1,FENG Wen-yu2,XIAO Shun-han1(1 Department of Pharmacology,2 Pharmacy Research Institute,Luzhou Medical College,Luzhou 646000,China) |
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| Abstract: | Objective: To investigate the effect of Fu-er-kang injection on the growth of hepatocellular carcinoma cells in vitro and tumor xenograft in vivo in nude mice.Methods: The cytotoxic effect of Fu-er-kang injection on hepatoma carcinoma SMMC-7721 and BeL-7402 cells was determined by CCK8 assay(cell counting kit-8).After SMMC-7721 cells were transplanted into BALB/c-nude mice,inhibitory effect of Fu-er-kang injection on tumor growth was evaluated by measuring tumor volume(TV),relative tumor volume(RTV) and rel... |
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| Keywords: | Fu-er-kang injection hepatocellular carcinoma cell nude mice |
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