| HPLC法测定盐酸吲哚美辛2-[2-(6-甲氧基-2-萘基)吗啉基]乙酯的平衡溶解度和脂水分配系数 |
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| 引用本文： | 凌伟,石磊,戴智勇,徐智.HPLC法测定盐酸吲哚美辛2-[2-(6-甲氧基-2-萘基)吗啉基]乙酯的平衡溶解度和脂水分配系数[J].中国新药杂志,2011(9). |
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| 作者姓名： | 凌伟 石磊 戴智勇 徐智 |
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| 作者单位： | 中南大学湘雅医院;中南大学药学院;湖南大学化学化工学院; |
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| 基金项目： | 2009年湖南省长沙市重点项目(K0901077-31) |
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| 摘 要： | 目的:测定盐酸吲哚美辛2-2-(6-甲氧基-2-萘基)吗啉基]乙酯在乙醇、乙腈、丙酮、乙酸乙酯等溶剂中的平衡溶解度以及在正辛醇-水和正辛醇-缓冲液体系中的表观油水分配系数。方法:采用HPLC法测定盐酸吲哚美辛2-2-(6-甲氧基-2-萘基)吗啉基]乙酯的浓度,采用摇瓶法测定其表观油水分配系数。结果:25℃时盐酸吲哚美辛2-2-(6-甲氧基-2-萘基)吗啉基]乙酯在乙醇、乙腈、丙酮、乙酸乙酯中的平衡溶解度分别为31.36,141.50,575.77,598.68 g.L-1。pH=4时此目的化合物的平衡溶解度最小,而表观油水分配系数最大。结论:盐酸吲哚美辛2-2-(6-甲氧基-2-萘基)吗啉基]乙酯的平衡溶解度及油水分配系数与介质的pH有关。其水溶性较差,脂溶性好。
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| 关 键 词： | 盐酸吲哚美辛2-[2-(6-甲氧基-2-萘基)吗啉基]乙酯 平衡溶解度 表观油水分配系数 高效液相色谱法 |
Determination of equilibrium solubility and apparent oil/water partition coefficient of indomethacin prodrug by HPLC |
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| LING Wei,SHI Lei,DAI Zhi-yong,XU Zhi.Determination of equilibrium solubility and apparent oil/water partition coefficient of indomethacin prodrug by HPLC[J].Chinese Journal of New Drugs,2011(9). |
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| Authors: | LING Wei SHI Lei DAI Zhi-yong XU Zhi |
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| Institution: | LING Wei1,2,SHI Lei3,DAI Zhi-yong1,XU Zhi1(1 Department of Pharmacy of Xiangya Hospital,Central South University,Changsha 410008,China,2 College of Pharmacy,Changsha 410013,3 College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China) |
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| Abstract: | Objective:To determine the equilibrium solubility of 2-2-(6-methoxynaphthalen-2-yl)morpholino]ethyl ester of indomethacin in various solvents such as ethanol acetonitrile acetone and ethyl acetate and its apparent oil/water partition coefficients in the n-octanol-water/buffer solution systems.Methods:The concentration of indomethacin prodrug was determined by HPLC,and the apparent oil/water partition coefficient was determined by shaking flask method.Results:The higher equilibrium solubility of indomethaci... |
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| Keywords: | 2-[2-(6-methoxynaphthalen-2-yl)morpholino]ethyl ester of indomethacin hydrochloride the equilibrium solubility apparent oil/water partition HPLC |
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