| 藻酸双酯钠对大鼠离体去内皮胸主动脉环的舒缩作用 |
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| 引用本文： | 郑高暑,胡申江,林杨闯. 藻酸双酯钠对大鼠离体去内皮胸主动脉环的舒缩作用[J]. 中国新药杂志, 2011, 0(24) |
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| 作者姓名： | 郑高暑 胡申江 林杨闯 |
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| 作者单位： | 浙江省温州医学院附属第一医院心内科;浙江大学医学院附属第一医院心内科;浙江省台州市立医院心内科; |
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| 摘 要： | 目的:观察藻酸双酯钠(polysaccharide sulfate,PSS)对离体大鼠胸主动脉平滑肌舒缩的影响。方法:采用大鼠离体去内皮主动脉环灌流模型,观察不同浓度PSS(5×10-2～5×102 mg.L-1)对基础状态及氯化钾(KCl)、去氧肾上腺素(PE)等试剂的血管收缩效应的影响。结果:不同浓度PSS对基础状态、KCl或PE的去内皮血管环收缩效应无明显影响。PSS(5×102 mg.L-1)对内钙释放及外钙内流引起的血管收缩效应无明显影响。结论:在5×10-2～5×102 mg.L-1浓度范围内,PSS对离体血管平滑肌没有明显舒缩作用。
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| 关 键 词： | 藻酸双酯钠 胸主动脉 血管平滑肌 血管收缩 血管舒张 |
Effect of polysaccharide sulfate in endothelium-denuded thoracic aortic rings isolated from rats |
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| ZHENG Gao-shu,HU Shen-jiang,LIN Yang-chuang. Effect of polysaccharide sulfate in endothelium-denuded thoracic aortic rings isolated from rats[J]. Chinese Journal of New Drugs, 2011, 0(24) |
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| Authors: | ZHENG Gao-shu HU Shen-jiang LIN Yang-chuang |
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| Affiliation: | ZHENG Gao-shu1,HU Shen-jiang2,LIN Yang-chuang3(1 Department of Cardiology,The First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China,2 Department of Cardiology,The First Affiliated Hospital of Medical School of Zhejiang University,Hangzhou 310003,3 Department of Cardiology,Taizhou Municipal Hospital,Taizhou 318000,China) |
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| Abstract: | |
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| Keywords: | polysaccharide sulfate(PSS) thoracic aorta vascular smooth muscle vasodilation vasoconstriction |
| 本文献已被 CNKI 等数据库收录！ |
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