| 经前平对PMS肝气逆证大鼠海马β-内啡肽表达的影响 |
| |
| 引用本文： | 马艳妮,李自发,张惠云. 经前平对PMS肝气逆证大鼠海马β-内啡肽表达的影响[J]. 山东中医药大学学报, 2008, 32(5): 426-427 |
| |
| 作者姓名： | 马艳妮 李自发 张惠云 |
| |
| 作者单位： | 山东中医药大学,山东济南250355 |
| |
| 基金项目： | 国家自然科学基金，山东省自然科学基金 |
| |
| 摘 要： | 目的:通过观察中药对中枢神经递质受体表达的影响,探讨中药治疗情志障碍及经前期综合征(PMS)的微观机制。方法:脉冲电流结合噪音刺激大鼠,造成肝气逆PMS模型。分别给予生理盐水、经前平颗粒灌胃,连续4个月经周期,免疫组化法检测海马β-内啡肽阳性细胞。结果:处于发情期的PMS大鼠β-内啡肽(β-EP)阳性细胞表达显著低于同一月经周期的正常鼠(P<0.05),经前平颗粒能够缓解焦虑症状,且可以使大鼠海马β-内啡肽阳性细胞明显增多(P<0.05)。结论:中药经前平颗粒可能通过调节中枢β-内啡肽的表达,而治疗与PMS有关的情志障碍。
|
| 关 键 词： | 经前期综合征 模型大鼠 β-内啡肽 免疫组化 实验研究 |
Effect of Jingqianping granule on the expression of β-EP receptor in hippocampi of PMS model rat with liver-Qi invasion |
| |
| MA Yan-ni,LI Zi-fa,ZHANG Hui-yun. Effect of Jingqianping granule on the expression of β-EP receptor in hippocampi of PMS model rat with liver-Qi invasion[J]. Journal of Shandong University of Traditional Chinese Medicine, 2008, 32(5): 426-427 |
| |
| Authors: | MA Yan-ni LI Zi-fa ZHANG Hui-yun |
| |
| Abstract: | Objective:To explore the micromechanism on feeling obstacle and premenstrual syndrome(PMS) by observing traditional Chinese medicine on the expression of the neurotransmiter receptor in neutron.Methods: To make the PMS model rat with liver-Qi invasion by stimulating the rat with pulse electric current and noises,then give the model rat different medicine for four menstrual periods,and check the positive cell of β-EP receptor in the rat hippocampi by immunohistochemistry method.Results: The positive cell expression of β-EP significantly lower in hippocampi of PMS model rat in the stage of oestrum than that of normal rat(P<0.05),Jingqianping granule can lower the anxiety symptom,and significantly increase the positive cell of β-EP of PMS rat model(P<0.05). Conclusion:Jingqianping granule could treat feeling obstacle related with PMS by controlling the expressin of β-EP receptor in central nervous system. |
| |
| Keywords: | premenstrual syndrome model rat β-EP immunohistochemistry experimental study |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
