| 普伐他汀和烟酸肌醇脂治疗原发性高胆固醇血症的比较 |
| |
| 引用本文： | 王维治,徐凯建,高清芳,赵晓和,阎晓波. 普伐他汀和烟酸肌醇脂治疗原发性高胆固醇血症的比较[J]. 中国新药与临床杂志, 1995, 0(2) |
| |
| 作者姓名： | 王维治 徐凯建 高清芳 赵晓和 阎晓波 |
| |
| 作者单位： | 卫生部哈尔滨医科大学临床药理基地，哈尔滨医科大学附属第二医院神经科 |
| |
| 摘 要： | 用双盲对照观察普伐他汀（Ｐｒａ）和烟酸肌醇脂（ＩＮ）的降血脂作用，随机分Ｐｒａ和ＩＮ组各３０例高胆固醇血症病人。男性４１例，女性１９例，年龄５７±ｓ９ａ（４０－７６ａ）．Ｐｒａ１０ｍｇ，ｐｏ，ｑｎ，ＩＮ０．４ｇｔｉｄ，均连服４ｗｋ。结果：Ｐｒａ组ＴＣ，ＴＧ和ＬＤＬ－ｃｈ治疗２ｗｋ后就有明显下降，Ｐ均＜０．０１，ＨＤＬ－ｃｈ上升，Ｐ＜０．０５，其药效明显强于ＩＮ，疗效随用药时间延长而提高，未见明显副作用。
|
| 关 键 词： | 普伐他汀；烟酸肌醇脂；胆固醇；三酰甘油；血胆固醇过多症 |
Pravastatin vs inositol nicotinate in treating primary hypercholesterolemia |
| |
| WANG Wei-Zhi,XU Kai-Jian,GAO Qing-Fang, ZHAO Xiao-He, YAN Xiao-Bo. Pravastatin vs inositol nicotinate in treating primary hypercholesterolemia[J]. Chinese Journal of New Drugs and Clinical Remedies, 1995, 0(2) |
| |
| Authors: | WANG Wei-Zhi XU Kai-Jian GAO Qing-Fang ZHAO Xiao-He YAN Xiao-Bo |
| |
| Abstract: | The effect of pravastain(Pra) for treatment of primary hypercholesterolemia was assessed in an inositol nicotinate(IN) controlled,double-blind trial.Sixty patients with hypercholesterolemia(M 41,F 19;age 57±s 9 a) were randomly divided into 2 groups treated with Pra 10 mg/d for 4 wk and with IN 0.4 g tid for 4 wk.The levels of TC 7.3±1.3mmol/L and TG 2.3±0.9mmol/L decreased to 5.5±1.3mmol/L and 1.3±0.9mmol/L.respectively.Good clinical effects of Pra were noted after 2 wk of receiving drugs and the effects further increased after 4 wk.The results revealed that Pra markedly reduced serum TC,TG,LDL-ch levels and TC-HDL-ch/HDL-ch-ratio and increased HDL-ch.Compared with IN,Pra showed stronger effects and very mild adverse reactions.Pra is a new remedy for treatment of hypercholesterolemia. |
| |
| Keywords: | pravastatin inositol nicotinate cholesterol triglycerides hypercholesterolemia |
| 本文献已被 CNKI 等数据库收录！ |
