| 氯化琥珀胆碱注射液中有关物质的检查 |
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| 引用本文： | 武向锋,靳守东,沈娟,魏立平.氯化琥珀胆碱注射液中有关物质的检查[J].解放军药学学报,2009,25(4):355-357. |
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| 作者姓名： | 武向锋 靳守东 沈娟 魏立平 |
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| 作者单位： | 总后勤部卫生部药品仪器检验所,北京,100071 |
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| 摘 要： | 目的建立氯化琥珀胆碱注射液中有关物质的测定方法。方法用薄层色谱法检查注射液中的氯化胆碱,用滴定法检查水解产物。结果薄层色谱法可以有效分离氯化琥珀胆碱注射液中的氯化胆碱和其它杂质,氯化胆碱的最低检出限为0.2μg,氯化琥珀胆碱对照品、1批氯化琥珀胆碱原料和3批氯化琥珀胆碱注射液中氯化胆碱的杂质量均〉2.0%。3批氯化琥珀胆碱注射液中的水解产物含量均〈3.0%。结论本法简便、快速,能控制氯化琥珀胆碱注射液中有关物质。
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| 关 键 词： | 有关物质 氯化琥珀胆碱 氯化胆碱 水解产物 |
Determination of Related Substances in Suxamethonium Chloride Injection |
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| WU Xiang-Feng,JIN Shou-Dong,SHEN Juan,WEI Li-Ping.Determination of Related Substances in Suxamethonium Chloride Injection[J].Pharmaceutical Journal of Chinese People's Liberation Army,2009,25(4):355-357. |
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| Authors: | WU Xiang-Feng JIN Shou-Dong SHEN Juan WEI Li-Ping |
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| Institution: | (Institute of Drug and Instrument Control of PLA, Beijing 100071 China) |
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| Abstract: | im To establish a method for quality control of related substances in suxamethonium chloride injection.Methods Choline choride in the injection was determined by thin-layer chromatography（TLC）,and hydrolysis products in the injection by titration.Results Choline choride and other related substances in the injection were separated by TLC.The lowest detectable limit of choline choride was 0.2μg.The limit of choline choride exceeded 3.0% in the suxamethonium chloride reference substance,one batch of suxamethonium chloride raw material,and three batchs of suxamethonium chloride injection.Hydrolysis products in three batchs of suxamethonium chloride injection were below 3.0%.Conclution This method is simple and fast,which can be used to control related substances in suxamethonium chloride injection. |
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| Keywords: | the related substances suxamethonium chloride choline choride hydrolysis products |
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