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| 联麦氧钒对小鼠糖尿病性心肌病的治疗作用 | |
| 引用本文： | 李杰,王春霞,孔俭,陈远芳,李才. 联麦氧钒对小鼠糖尿病性心肌病的治疗作用[J]. 中国老年学杂志, 2001, 21(2): 129-131 |
| 作者姓名： | 李杰 王春霞 孔俭 陈远芳 李才 |
| 作者单位： | 1. 吉林大学第一医院干部病房,长春 1 30021 2. 吉林大学第一医院干部病房,长春 130021 3. 解放军第465医院内科 4. 吉林大学应用基础研究所 |
| 基金项目： | 吉林省科委资助课题(97588-2) |
| 摘 要： | 目的 探讨联麦氧钒对大鼠糖尿病心肌病的治疗作用。方法 选用Wistar大鼠腹腔内注射链脲佐菌素制备糖尿病模型。合成联麦氧钒,溶于饮水中（浓度1g/L)治疗糖尿病大鼠12W,测血管、血脂等,取心肌组织进行病理学检查。结果 DV组血糖、血脂、饮水量等明显降低,心肌 细胞结构基本正常,但胰岛素水平维持较低。结论 联麦氧钒可以通过增加胰岛素作用效率,降低血糖、血脂、恢复糖尿病大鼠心肌细胞的结构和功能。 |
| 关 键 词： | 联麦氧钒 糖尿病性心肌病 高脂血症 胰岛素 |
| 文章编号： | 1005-9202(2001)02-0129-03 |
| 修稿时间： | 2000-04-28 |
The effects ofbis(maltolato) oxovanadium(IV) on diabetic cardiomyopathy of rats |
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| Abstract: | Objective To study the effects of BMOV on d iabeticcardiomyopathy of rats.Methods Wistar rats were chosen and administered with str eptozocin in abdominal cavity.The synthetic BMOV was administered to diabetic ra ts in drinking water for 12 weeks at the concentration of 1 g/L.The major indexe s were blood glucose,lipids and heart tissue pathologic examination.Results For all diabetic-treated animals BMOV intake was accmpanied by lowered plasma concentration of glucose and lipids with no asscoc iated enhancement of circulating insulin and by nearly normalized morphologic fe atures of myocardium.Conclusions BMOV could reduce the plasma levels of glucos e and lipids by improving the effectiveness of insulin and recover the construct ion and function of diabetic hearts. |
| Keywords: | ? Bis(maltolato) oxovanadium IV Diabetic cardiomyopathy Hyperlipidemia Insulin |
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