Delayed cytotoxic effects of methyl jasmonate and cis-jasmone induced apoptosis in prostate cancer cells |
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| Authors: | Yeruva Laxmi Pierre Keon J Bathina Madhavi Elegbede Abiodun Carper Stephen W |
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| Institution: | Cancer Research Center/Chemistry Department, University of Nevada, Las Vegas, Las Vegas, Nevada, USA. yeruvavenkatl@uams.edu |
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| Abstract: | Advanced prostate cancer cells are typically hormone independent, resistant to apoptosis and do not respond to chemotherapeutic agents. The ability of methyl jasmonate (MJ) and cis-jasmone (CJ) to inhibit growth in hormone independent prostate cancer cell lines, PC-3 and DU-145, was evaluated. CJ and MJ inhibited cell growth, induced cell cycle arrest and apoptosis. Detailed studies with the PC-3 cell line revealed that 2 mM CJ or MJ treatment resulted in caspase 3 activation and Tumor Necrosis Factor Receptor 1 (TNFR1) activation, all hallmarks of apoptosis. These phytochemicals could be useful in the management of advanced prostate cancer. |
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