补肾生血方药对慢性肾功能不全性贫血大鼠红细胞生成素基因表达的影响

用腺嘌呤饲喂大鼠，建立慢性肾功能不全性贫血动物模型，观察肾功能损伤与网织红细胞、血红蛋白和红细胞生成素（ＥＰＯ）合成之间的关系，探讨补肾生血中药改善造血机能的作用机理。结果表明，中药可显著降低肾功能不全大鼠血清肌肝和血尿素氮，并通过促进ＥＰＯ基因表达来改善动物的贫血状况。

Effect of Bushen Shengxue Recipe on EPO Gene Expression of Chronic Renal Insufficiency Anemia in Rats

The rats were fed with adenine to establish the chronic renal insufficiency anemia model,and the relationship between renal functional impairment and reticulocytes,hemoglobin and erythropoietin(EPO) synthesis was observed to explore the mechanism of Bushen Shengxue drugs in improving the hemopoietic function.The results showed that the Bushen Shengxue drugs could significantly lower the serum creatinine and blood urea nitrogen of renal insufficiency rats,and through the promotion of EPO gene expression,the animals,anemic status was improved.