人体大脑数字化解剖模型的构建及可视化

目的构建人体大脑数字化解剖模型，为实现大脑的计算机精确模拟提供可操作的基础平台，为人体大脑功能研究提供解剖学框架。方法采用低温冷冻铣切技术采集人体大脑的横断面图像，用课题组自行开发的软件，将分割提取后的脑断面图像进行重建，建立大脑三维模型。用与香港中文大学合作开发的可视化软件，在三维空间上对人体大脑结构进行可视化研究。结果建立了以前后连合间线中点为原点的大脑三维模型，且模型上每一像素都有相应的解剖标识，其任意一点的坐标均能显示；大脑的三维模型可以任意切割显示大脑内部结构：重构后的大脑结构还可进行三维测量。结论大脑数字化模型建立在临床常用的三维空间坐标系中且模型上每一像素都有相应的解剖标识，为模型驱动分割算法的研究提供了模板，同时也为神经解剖教学提供了一种新的、直观的手段。具有明确解剖标识和量化空间信息的数字化人大脑模型，与坐标系统联系起来，还为人大脑各类图像配准提供了公共参考系统。

CONSTRUCTION OF DIGITIZED ANATOMICAL MODEL AND VISUALIZATION OF HUMAN CEREBRUM

Objective Building the digitized anatomical model of human cerebrum for providing platform for exact simulation of cerebrum on the computerized and functional study of cerebrum. Methods Visible human technique was used to collect human cerebrum data.The main structures of cerebrum were reconstructed and visualized on personal computer by using the software for tridimensional reconstruction exploited by our research group and the VR software provided by the Chinese University of Hong Kong. Results A three-dimensional digitized anatomical model of human cerebrum based on the midpoint of the intercommissural line was established. Each element of the model was associated with a nametag. According to initial transverse sectional images, we can display sagittal, coronal, and other directional sections of cerebrum by computerized 3D reconstruction;and the reconstructed cerebral structures can be measured in 3D space. Conclusion Each voxel of the model is assigned a nametag and the model has tridemensional coordinate system on the midpoint of intercommissural line, often used in clinic, which made the model be used for visualization in surgical planning,for model driven segmentation and for the teaching of neuroanatomy.