Prefrontal hemodynamic activity predicts false memory--a near-infrared spectroscopy study |
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Authors: | Kubota Yasutaka Toichi Motomi Shimizu Mitsue Mason Richard A Findling Robert L Yamamoto Kokichi Calabrese Joseph R |
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Institution: | Mood Disorders Program, Department of Psychiatry, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, OH 44106, USA. yka@sue.shiga-u.ac.jp |
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Abstract: | Evidence from lesion studies suggests an important role of the prefrontal cortex (PFC) in the reconstructive processes of episodic memory or memory distortion. Results from functional imaging studies imply PFC involvement during the illusionary recollection of non-experienced events. Here, we used a two-channel near-infrared spectroscopy (NIRS) system and conducted real-time monitoring of PFC hemodynamics, while subjects studied word lists and subsequently recognized unstudied items (false recognition). Bilateral increases in the oxygenated hemoglobin concentration (oxy-Hb]) were observed during false recognition compared to true recognition, and a left PFC dominant increase of oxy-Hb] was observed during encoding phases where subjects later claimed that they recognized unstudied words. Traces of semantic processing, reflected primarily in the left PFC activity, could eventually predict whether subjects falsely recognize non-experienced events. |
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