| 瘤细胞内P53蛋白聚集与脑胶质细胞瘤患者预后的关系 |
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| 引用本文： | 许涛,马大烈.瘤细胞内P53蛋白聚集与脑胶质细胞瘤患者预后的关系[J].中国临床神经科学,1997,5(4):196-198. |
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| 作者姓名： | 许涛 马大烈 |
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| 作者单位： | 上海市长海医院神经外科 200433
(许涛，岳志健，周晓平)，上海市长海医院病理科 200433
(马大烈，黄玲)，上海市长海医院神经外科 200433(王文仲) |
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| 摘 要： | 采用微波免疫组织化学染色方法对54例经外科治疗的脑肿瘤随访标本进行研究。结果显示在47例随访超过或达到2年的脑肿瘤患者中,P53的阳性率为40.4％,P53阳性与脑肿瘤患者预后不相关(X~2=0.723。P>0.05)。在Ⅰ～Ⅱ级星形细胞瘤中,P53阳性率为48.3％,其与预后有明显统计学的意义(X~2=4.15,P<0.05)。这表明P53在Ⅰ～Ⅱ级星形细胞瘤中有着更为密切的关系并在其发生、发展上起着重要的作用。
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| 关 键 词： | 星形细胞瘤 P53蛋白 微波 免疫组化 |
The Relationship Between P53 Accumulation and Gliomas Prognosis |
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| Xu Tao,Ma Da-Lie,Huang Ling,Yue Zhi-Jian,Zhou Xiao-Ping,Wang Wen-Zhong.The Relationship Between P53 Accumulation and Gliomas Prognosis[J].Chinese Journal of Clinical Neurosciences,1997,5(4):196-198. |
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| Authors: | Xu Tao Ma Da-Lie Huang Ling Yue Zhi-Jian Zhou Xiao-Ping Wang Wen-Zhong |
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| Institution: | Xu Tao,Ma Da-Lie,Huang Ling,Yue Zhi-Jian,Zhou Xiao-Ping,Wang Wen-Zhong Department of Neurosurgery,Changhai Hospital,Shanghai 200433 |
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| Abstract: | The P53 immunohistochemical staining by microwaves was processed in 54 patients withbrain neoplasms treated with surgery. P53 immunostaining was detected in nuclei in 19 out of47 patients with 2 years or more than follow-up. The rest was P53-negative group. Therewere no remarkable differences between the two groups in prognosis. P53 presented, however,at 48.3 % in the low-grade astrocytomas. There were significantly statistical differencesbetween the positive and the negative groups in prognosis (X2 = 4.15, P<0. 05). The resultsmanifested that there was a close correlation between low-grade astrocytomas and the P53,which may play a key role in the occurrence and development of the neoplasm. |
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| Keywords: | Astrocytoma P33-protein Microwave Immunohistochemistry |
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