雅施达治疗充血性心力衰竭的临床研究

目的观察雅施达（培哚普利）治疗充血性心力衰竭（CHF）的临床疗效。方法118例经常规洋地黄、利尿剂、血管扩张药等治疗效果欠佳的CHF患者,给予口服雅施达2-4 mg/d,治疗4-6周。观察治疗前后心率、心胸比、血压、左室舒张末期内径、左室射血分数以及心功能变化。结果治疗后心率、心胸比、血压以及左室舒张末期内径与治疗前比较均明显下降（P〈0.05）,左室射血分数增加（P〈0.05）,心功能改善1-2级。药物副作用少,患者耐受性好。结论雅施达治疗CHF疗效好,副作用少,是比较理想的治疗药物。

The clinical study of Acertil in treating congestive heart failure

Objective: To investigate the clinical study of Acertil(Perindopril) in treating congestive heart failure.Methods: 118 patients,who had unsatisfactory results under conventional Digitoras,Diuretics,Vasodilators therapy,were given Acertil 2 ~4 mg orally once a day for 4 ~6 weeks.The changes of heart rate(HR),blood pressure(BP),cardiothoracic ratio,left ventricular and diastolic diameter(LVDd),left ventricular ejection fraction(LVEF) and cardiac function(NYHA) were observed.Results: After 4 ~6 weeks by the therapy,HR BP cardiothoracic ratio and LVDd all decreased significantly(P<0.05);LVEF increased(P<0.05);Cardiac function(NYHA) improved by 1 ~2 grade.Acertil had few adverse effects and patients tolerance was perfect.Conclusion: The effect of Acertil in treating congestive heart failure is satisfactory.Acertil has little adverse effect and is effective for congesitive heart failure.