黄酮类化合物调节肥胖相关炎症的研究进展

随着人们生活水平的提高,肥胖人口数量急剧增加。肥胖可诱导巨噬细胞浸润到脂肪组织,产生一系列生理变化,进而引发慢性炎症,并可进一步发展成代谢综合征、心血管疾病等多种慢性疾病。黄酮类化合物广泛存在于植物中,大量研究表明,黄酮类化合物可通过抑制巨噬细胞的浸润、调节信号转导及抗氧化等途径抑制肥胖相关炎症,并降低与其相关慢性疾病的发生风险。从肥胖诱导炎症相关的发病机制出发,概述近年来黄酮类物质抑制肥胖所诱导的慢性炎症的作用机制研究进展。黄酮类化合物在调控代谢炎症及其相关疾病方面有广阔应用前景,筛选更多有效的黄酮类化合物并研究其作用机制,具有重要的理论与临床应用价值。

Regulation of obesity-induced inflammation by flavonoids

With the improvement of living standards, the population of obese people increased dramatically. Obesity can induce macrophage infiltration into adipose tissue, which can cause a series of physiological changes, resulting in chronic inflammation which would further develop into a variety of chronic diseases such as metabolic syndrome, cardiovascular disease, cancer, etc. Flavonoids are a class of natural compounds widely found in plants. Flavonoids can prevent metabolic inflammation and corresponding chronic diseases through inhibiting macrophage infiltration, regulating signal transduction and anti-oxidation, etc. In this review, recent findings about the pathogenesis of obesity-induced inflammation and the effects of flavonoids on treatment of such chronic inflammation are summarized and discussed. Flavonoids have great application potentials in regulation of metabolic inflammation, thus screen more potential active flavonoids and elucidating their mechanism would have both theoretical and clinical significance.