子宫内膜细胞生长和分化中基质-上皮相互作用的研究进展

子宫内膜由上皮、基质细胞等成分构成，它们之间的相互作用在子宫内膜周期性变化中的作用机制还不清楚。近年来，随着各种新技术的出现，对于子宫内膜功能的分子机制有了更深入的认识。深入研究基质-上皮相互作用具有重要意义，不仅可以揭示子宫内膜发生、生长、分化的过程，而且可以对子宫内膜异位症和子宫内膜癌等内膜相关疾病的防治提供有效的手段。本文就子宫内膜基质-上皮相互作用在子宫内膜增殖和分化中的研究，参与基质-上皮相互作用的重要因子，以及基质-上皮相互作用在子宫内膜相关疾病中研究的最新进展进行简要综述。

Role of stromal-epithelial interaction in growth and differentiation of the endometrium

Human endometrium, mostly consisted of epithelial and stromal cells, undergoes characteristic changes of morphology and function in every menstrual cycle regulated by a sequential effect of estradiol and progesterone. Although little was known about the mechanisms of stromal-epithelial interaction, it is clear that stromal-epithelial interaction plays an important role in menstruation. Great advances on the molecular mechanisms of stromal-epithelial interaction have been made recently due to the latest developemt on techniques. To elucidate the underlying mechanisms of stromal-epithelial interaction will not only help to understand the growth and differentiation of the endometrium, but also will provide the potential therapeutical targets on endometriosis and cancer of endometrium. Hence, this article will focus on the advances in researches on the role of stromal-epithelial interaction in the endometrium.