Circulating YKL-40 levels during human endotoxaemia |
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Authors: | Johansen J S Krabbe K S Møller K Pedersen B K |
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Affiliation: | Department of Rheumatology Q107, University of Copenhagen, Herlev Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark. julia.johansen@post3.tele.dk |
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Abstract: | YKL-40 is secreted by macrophages and neutrophils and patients with bacterial infections have elevated circulating YKL-40. The aim was to evaluate changes in plasma YKL-40 (determined by enzyme-linked immunosorbent assay (ELISA) at 0, 2, 4, 8, 24 and 32 h) in eight healthy volunteers after injection with Esherichia coli endotoxin or saline. Plasma YKL-40 increased after endotoxin injection from 31 microg/l (range 19-39 microg/l) to a maximum of 159 microg/l (61-552 microg/l, P < 0.01) at 24 h. The finding that plasma YKL-40 increased after endotoxin injection compared with saline (P < 0.001) suggests that YKL-40 has a functional role in infections. |
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Keywords: | CHI3L1 endotoxin HC‐gp39 TNF‐α YKL‐40 |
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