| 宫腔注射纤连蛋白抗体和层粘蛋白抗体对小鼠胚泡着床的影响 |
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| 引用本文： | 武玉玲,邴鲁军,王富武,李少玲,宋卫华. 宫腔注射纤连蛋白抗体和层粘蛋白抗体对小鼠胚泡着床的影响[J]. 解剖学杂志, 2000, 23(4): 313-316 |
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| 作者姓名： | 武玉玲 邴鲁军 王富武 李少玲 宋卫华 |
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| 作者单位： | 山东医科大学组织学与胚胎学教研室,济南,250012 |
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| 基金项目： | 山东省自然科学基金资助项目 |
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| 摘 要： | 目的：主要研究纤连蛋白抗体和层粘连蛋白抗体对胚泡着床的影响，方法：取孕４天小鼠，分别在两侧子宫角内注射纤连蛋白及层粘连蛋白抗血清，于孕８天检查胚胎床数，取子宫观察内膜的组织学及免疫组织化学变化。结果：纤维蛋白抗血清及层粘连蛋白抗血清均有显著抑制胚泡着床的效应，组织学及免疫组化结果表明，纤连蛋白抗血清及层粘连蛋白抗血清可引起蜕膜细胞退化解体，拮抗纤维蛋白及层粘连蛋白在脱膜组织中的表达，结论：纤连蛋白
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| 关 键 词： | 纤连蛋白 层粘连蛋白 胚泡 着床 抗体 宫腔注射 |
EFFECT OF INTRA-UTERUS INJECTION OF FIBRONECTIN ANTISERUM AND LAMININ ANTISERUM ON BLASTOCYST IMPLANTATION IN MICE |
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| Wu Yuling,Bing Lujun,Wang Fuwu,Li Shaoling,Song Weihua. EFFECT OF INTRA-UTERUS INJECTION OF FIBRONECTIN ANTISERUM AND LAMININ ANTISERUM ON BLASTOCYST IMPLANTATION IN MICE[J]. Chinese Journal of Anatomy, 2000, 23(4): 313-316 |
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| Authors: | Wu Yuling Bing Lujun Wang Fuwu Li Shaoling Song Weihua |
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| Affiliation: | Wu Yuling ,Bing Lujun ,Wang Fuwu,Li Shaoling ,Song Weihua ;(Shandong Medical University, Jinan 250012) |
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| Abstract: | To evaluate the effects of specific fibronectin(FN) antiserum and laminin(LN) antiserum on mice blastocyst implantation. Methods: Pregnant mice were given FN antiserum and LN antiserum by intra uterus injection. The numbers of embryo implantation were examined and the histological and immunohistochemical variances in endometrium were observed. Results: Both FN antiserum and LN antiserum produced significant effects on repressing mouse blastocyst implantation. Conclusion: FN and LN in mice may play an important role in the process of blastocyst attachment and implantation. |
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| Keywords: | fibronectin laminin blastocyst implantation |
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