| 伴t(8;21)(q22;q22)易位的急性双表型白血病的临床研究 |
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| 引用本文： | Guangsheng He Ling Zhou Depei Wu Yongquan Xue Mingqing Zhu Jianying Liang Aining Sun Zhengming Jin Huiying Qiu Miao Miao Xiaowen Tang Zhengzheng Fu Xiao Ma Xiuli Wang. 伴t(8;21)(q22;q22)易位的急性双表型白血病的临床研究[J]. 中德临床肿瘤学杂志, 2007, 6(4): 389-392. DOI: 10.1007/s10330-007-0054-z |
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| 作者姓名： | Guangsheng He Ling Zhou Depei Wu Yongquan Xue Mingqing Zhu Jianying Liang Aining Sun Zhengming Jin Huiying Qiu Miao Miao Xiaowen Tang Zhengzheng Fu Xiao Ma Xiuli Wang |
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| 作者单位： | Jiangsu Insitimte of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215006, China |
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| 基金项目： | Supported in part by the Natural Science Fund of Jiangsu Province （2004BK424）, the 135 Key Department Fund of Jiangsu Province （135XY0416）, and the 0utstanding Person Fund of First Affiliated Hospital of Soochow University （2004YQG05）. |
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| 摘 要： | Objective： To report 4 cases of biphenotypic acute leukemia （BAL） with t（8;21）（q22;q22）, and analyze the characteristics of morphology, immune phenotype, chromosome karyotype （MIC） and clinical manifestations. Methods： The BAL patients with t（8;21）（q22;q22） （group A） were compared with the randomly selected BAL patients with other clonical chromosomal changes （group B） and acute myeloid leukemia M2 cases with t（8;21）（q22;q22） （group C） in MIC and clinical features. Results： BAL with t（8;21）（q22;q22） showed acute myeloid leukemia with high percentages of blast cells morphologically; revealed co-positive to B-lymphoid and myeloid lineages, frequent and high expressions of CD34 and CD33; were responsive to chemotherapy for myeloid and lymphocytic leukemia simultaneously well. Conclusion： A new subset of BAL with t（8;21）（q22;q22） was reported, and this suggests that the leukemia colony with t（8;21）（q22;q22） might originate from early phase of hematopoiesis.
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| 关 键 词： | t（8：21）（q22：q22） 基因易位 急性双表型 白血病 临床研究 |
| 收稿时间： | 2007-02-22 |
| 修稿时间： | 2007-02-22 |
Clinical research of biphenotypic acute leukemia with t(8;21)(q22;q22) |
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| Guangsheng He,Ling Zhou,Depei Wu,Yongquan Xue,Mingqing Zhu,Jianying Liang,Aining Sun,Zhengming Jin,Huiying Qiu,Miao Miao,Xiaowen Tang,Zhengzheng Fu,Xiao Ma,Xiuli Wang. Clinical research of biphenotypic acute leukemia with t(8;21)(q22;q22)[J]. The Chinese-German Journal of Clinical Oncology, 2007, 6(4): 389-392. DOI: 10.1007/s10330-007-0054-z |
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| Authors: | Guangsheng He Ling Zhou Depei Wu Yongquan Xue Mingqing Zhu Jianying Liang Aining Sun Zhengming Jin Huiying Qiu Miao Miao Xiaowen Tang Zhengzheng Fu Xiao Ma Xiuli Wang |
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| Affiliation: | Jiangsu Insitimte of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215006, China |
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| Abstract: | Objective:To report 4 cases of biphenotypic acute leukemia(BAL)with t(8;21)(q22;q22),and analyze the characteristics of morphology,immune phenotype,chromosome karyotype(MIC)and clinical manifestations.Methods:The BAL patients with t(8;21)(q22;q22)(group A)were compared with the randomly selected BAL patients with other clonical chromo- somal changes(group B)and acute myeloid leukemia M2 cases with t(8;21)(q22;q22)(group C)in MIC and clinical features. Results:BAL with t(8;21)(q22;q22)showed acute myeloid leukemia with high percentages of blast cells morphologically; revealed co-positive to B-lymphoid and myeloid lineages,frequent and high expressions of CD34 and CD33;were responsive to chemotherapy for myeloid and lymphocytic leukemia simultaneously well.Conclusion:A new subset of BAL with t(8;21)(q22;q22)was reported,and this suggests that the leukemia colony with t(8;21)(q22;q22)might originate from early phase of hematopoiesis. |
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| Keywords: | leukemia biphenotypic acute t(8 21)(q22 q22) clinical |
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