甲状旁腺素对尿毒症患者红细胞免疫功能的影响

目的　探讨甲状旁腺素 (PTH)与尿毒症患者红细胞免疫功能的关系。方法　采用红细胞受体花环率(E C3 bRR)和红细胞免疫复合物花环率 (E ICRR)测定尿毒症患者的红细胞免疫功能 ,观察血清PTH对尿毒症患者红细胞免疫功能的影响。结果　尿毒症患者的E C3 bRR明显低于正常人 ,而E ICRR明显增高 (P均 <0 .0 1) ,血清PTH与E C3 bRR呈显著负相关 (r= 0 .73,P <0 .0 1) ,与E ICRR呈显著正相关 (r =0 .4 9,P <0 .0 1)。尿毒症患者经促红细胞生成素 (EPO)治疗后 ,PTH轻、中度增高组与显著增高组患者比较 ,其E C3 bRR的升高和E ICRR的下降均有改善 (P <0 .0 5 )。结论PTH抑制红细胞免疫功能并影响EPO改善红细胞免疫的功能。

Effect of Parathormone on Immune Function of Red Blood Cell in Uremia Patients

objective To investigate the relationship between PTH and the immune function of RBC in uremia patients. Methods Erythrocyte C_3b receptor ring rate(E-C_3bRR) and Erythrocyte-immune complexion ring rate(E-ICRR)were applied as an index of the immune function of RBC.PTH level in serum was quantitated by radioimmunoassay. Results Compared with the normal control,E-C_3bRR was significantly decreased,while E-ICRR was remarkably increased in the uremia patients (both P<0.01). It was also found PTH level was negatively correlated with E-C_3bRR(r=-0.73,P<0.01),but positively with E-ICRR(r=0.49,P<0.01).After administration of erythropoietin (EPO),E-C_3bRR and E-ICRR were both improved in the uremia patients,PTH level (both P<0.05). Conclusion PTH can suppress the immune function of RBC,and inhibit the improvement of EPO's effect on it.