三个品种豚鼠血液蛋白多态性的比较分析

新生隐球菌是一种具荚膜的酵母样真菌，主要侵犯中枢神经系统和肺脏，好发于免疫功能低下的成人。近年来隐球菌病的发病率越来越高，因而引起国内外真菌学家的高度重视。系统研究新生隐球菌感染导致疾病的关键是动物实验。该菌感染最常用的动物模型主要是小鼠、大鼠和豚鼠，其他动物如兔、猪和一些非哺乳动物也已被用于制作新生隐球菌动物模型。这些动物模型的构建对进一步研究新生隐球菌发病机制、免疫学变化、疫苗的开发和有效的药物的筛选等有极其重要的作用，现就近几年新生隐球菌感染动物模型的进展作一综述。

Analysis of Blood Protein Polymorphism in WHBE Guinea Pig,DHP Guinea Pig and Pigmented Guinea Pig

Cryptococcus neoformans is an encapsuled yeast-like fungus. It is infectious and mainly damages pulmonary tissue and central nervous system. Adult with immunodepression is prone the infection of Cryptococcus neoformans. The mortality of Cryptococcus neoformans has increased significantly in the recent decade, which caused concerns of the researchers globally. Animal models played very important roles in the systemic exploration of the mechanism of infection. Mice, rats and guinea pigs were used numerously to develop Cryptococcus neoformans infection models. Pigs, rabbits and some non-mammals were also employed as candidates to develop animal models in drug development. These kind of animal models were crucial in the research of mechanism, immunology and treatment regimen of Cryptococcus neoformans. This article is to address the current situation of development of Cryptococcus neoformans animal models, and to sum up the achievements in this field.