绝经后2型糖尿病患者骨密度与颈动脉内膜中膜厚度的关系

目的 探讨绝经后2型糖尿病患者骨密度与颈动脉内膜中膜厚度的关系.方法 选择符合纳入标准的93例绝经后2型糖尿病患者和55例健康对照者,测定其正位腰椎L_(1～4)及左股骨颈骨密度,并根据骨密度将2型糖尿病患者分为并发骨质疏松症组和无骨质疏松症组,同时测定颈动脉内膜中膜厚度,并收集三组患者的年龄、绝经年限、体质指数等资料.结果 骨质疏松症组与无骨质疏松症组比较年龄、绝经年限、病程及体质指数差异有统计学意义(P<0.01);与无骨质疏松症组和对照组比较,骨质疏松症组正位腰椎L_(1～4)、左股骨颈骨密度下降(P<0.01),颈动脉内膜中膜厚度增厚(P<0.01),斑块发生率增高(P<0.05).相关分析显示,2型糖尿病患者正位腰椎L_(1～4)和左股骨颈骨密度与患者年龄、病程、绝经年限及颈动脉内膜中膜厚度呈负相关,与体质指数呈正相关.结论 绝经后2型糖尿病患者骨密度与颈动脉体质指数存在一定的联系,低骨密度绝经后2型糖尿病患者更易发生动脉粥样硬化.

The Relationship Between Bone Minerals Density and Carotid Intima-Media Thickness of Postmenopausal Patients with Type 2 Diabetes

Aim To discuss the relationship between bone minerals density (BMD) and carotid intima-media thickness (IMT) of postmenopausal patients with type 2 diabetes (T2DM).Methods 93 cases of postmenopausal patients with T2DM and 55 cases of control group were recruited. BMD on lumbar spine L_(1～4) and left femoral neck BMD were measured, and T2DM patients were divided into concurrent osteoporosis group (OP group) and non osteoporosis group (NOP group) according to BMD, with measuring carotid IMT, and collecting patients' age, duration of menopause and BMI etc.Results Comparing OP group with NOP group, the difference between age, duration of menopause, course of disease and BMI had statistical significance (P < 0.01);compared with NOP group and control group, in OP group lum-bar spine L_(1～4) and left femoral neck BMD decreased (P<0.01), carotid IMT thickens (P<0.01) and the plaque occur-fence rate increased (P < 0.05). Relative analysis showed that the lumbar spine L_(1～4) and left femoral neck BMD of T2DM group had negative correlation with age, duration of menopause, course of disease and carotid IMT, and positive correlation with BML Conclusion The BMD of postmenopausal patients with T2DM has certain relationship with carotid IMT. The postmenopausal patients with T2DM whose BMD is low are more susceptible to atherosclerosis.