海洋鱼皮胶原低聚肽对人体抗氧化作用研究

目的 探讨口服海洋鱼皮胶原肽对人体的抗氧化作用.方法 选择年龄在45～65岁的身体健康志愿者100人,分别随机分为试验组和对照组(各50例),进行口服抗氧化功能试验.受试者每天摄人海洋鱼皮胶原肽2.7g,连续90 d.在试验开始前和试验后分别测定血清抗氧化指标,包括超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH - Px)、丙二醛(MDA),以及测定血常规、大小便常规和血生化指标,并在试验的前中后期调查受试者疲劳感、烦躁、睡眠、干涩等不适症状的变化.结果 健康受试者口服海洋鱼皮胶原肽后,血清SOD的水平由(78.38±18.94)U/ml增加至(80.99±19.86)U/ml,前后对比差异无统计学意义(P＞0.05),与对照组相比差异无统计学意义(P＞0.05)；血清GSH - Px的水平由(79.03 - 15.12) U/ml增至(89.95±14.16) U/ml,自身对照及组间对照差异有统计学意义(均P＜0.01)；血清MDA的水平由(9.46 ±3.18)降至(6.87±3.57),自身对照及组间对照差异有统计学意义(均P＜0.01).对照组受试者3项指标在试验前后差异均无统计学意义(均P＞0.05).口服海洋鱼皮胶原肽受试者健忘、腰酸膝软等不适症状较对照组有明显改善,并且其症状积分在试验前、中、结束时均的逐渐降低,试验结束时的症状积分与试验前相比有统计学意义(P＜0.05).口服海洋鱼皮胶原肽受试者血常规、大小便常规和血生化检查结果均无明显异常,亦未见过敏反应.结论 口服海洋鱼皮胶原肽具有抗氧化作用,并有助于改善疲劳感、烦躁、睡眠、干涩等不适症状.

On Anti-oxidative Effects of Oral Administrationof Marine Collagen Peptides

Objective To study the anti-oxidative effects of oral administration of marine collagen peptides(MCP).Methods Totally 100 healthy adults aged 45-65 were selected and divided respectively into normal control groups(NCG) and trial groups(TG) with 50 persons each.Individuals in TG ingested 2.7g/d MCP for 90 days.Items such as SOD,GSH-Px and MDA,which can indicate antioxidative effects were measured,and routine analysis of blood,urine,feces and biochemical analysis of blood were measured;senses of fatigue,fidget,insomnia and acerbity were evaluated.Results The average level of SOD in TG was increased from(78.38±18.94)U/ml to(80.99±19.86)U/ml after intervention by taking MCP,with no statistical difference(P>0.05).The average level of GSH-Px in TG was increased from(79.03±15.12)U/ml to(89.95±14.16)U/ml after intervention by taking MCP(P<0.01).The average level of MDA in TG was declined from(9.46±3.18)U/ml to(6.87±3.57)U/ml after intervention by taking MCP(P<0.01).The P values on GSH-Px and MCP were all below 0.01 compared with those of the initial TG and NCG.The senses of fatigue,fidget,insomnia and acerbity were improved by oral MCP with a high effectiveness ratio.The symptom values at the beginning,metaphase and in the end declined obviously(P<0.01),and the P value was less than 0.01 compared with NCG.No abnormal changes were observed in routine analysis of blood,urine,feces and biochemical analysis of blood,and no hypersusceptibility was observed either.Conclusion The results indicate that MCP has anti-oxidation property and is helpful of getting rid of discomfort symptoms such as fatigue,fidget,insomnia,etc.