In vivo alpha 2-adrenoceptor-mediated inhibition of isoproterenol-stimulated free fatty acid output in dog bone marrow adipose tissue |
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| Authors: | M A Tran L D Tran M Berlan M Lafontan |
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| Institution: | 1. Laberatore de Physcologie Appliquee et Pharmacolofie Médicale ( Pr. Montastrue), Faculté de Médecine, 37, All/''e Jules Guesde 31000 Toulousc, France;2. Institute de Physcolofie, Université Paul Sabatier, ERA 412 CNRS, Rue François Magendie, 31000 Toulouse, France |
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| Abstract: | Clomdine, an α2 agonist, inhibited the isoproterenol-induced free fatty acid outflow from perfused bone marrow adipose tissue of dog tibia. This effect was suppressed by the α2-antagonist, yohimbine. These in vivo experiments clearly demonstrate an α2-adrenoceptor-mediated inhibition of isoproterenol-induced lipid mobilization and argue for a physiological interplay between β- and α2-site stimulation in the regulation of lipolysis. |
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| Keywords: | Bone marrow adipose tissue FFA release Yohimbine Clonidine Isoproterenol |
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