Presynaptic serotonin receptors regulate [3H]serotonin release from rat spinal cord synaptosomes |
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| Authors: | K A Stauderman D J Jones |
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| Affiliation: | 1. Department of obstetrics and gynecology, University of North Carolina hospitals;2. Graduate Program in Life Sciences - Epidemiology and Human Genetics Program, University of Maryland, Baltimore;3. Department of Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD |
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| Abstract: | Superfused rat spinal cord synaptosomes were studied to determine if inhibitory serotonin (5-HT) receptors (autoreceptors) exist on spinal serotonergic nerve terminals. Exogenous 5-HT (1-50 nM) produced a concentration-dependent inhibition of K+-induced [3H]5-HT release but did not affect basal [3H]5-HT release. A 32-44% inhibition was produced by 30 nM 5-HT. The inhibitory effect of 30 nM 5-HT was effectively antagonized by 100 nM metitepine, a 5-HT autoreceptor antagonist. The results provide evidence for the existence of 5-HT autoreceptors in rat spinal cord tissue. |
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