Ocular autonomic function in progressive autonomic failure |
| |
Authors: | Mr. Charles V. Clark M.D. David J. Ewing |
| |
Affiliation: | (1) University Departments of Ophthalmology and Medicine, The Royal Infirmary, EH3 9YW Edinburgh, UK;(2) Department of Ophthalmology, Eye Pavilion, Chalmers Street, EH3 9HA Edinburgh, UK |
| |
Abstract: | Ocular autonomic function was assessed in 4 patients with progressive autonomic failure (PAF) and age-matched control subjects, by measurement of the pupil cycle time, and determination of autonomic denervation hypersensitivity of the iris. Pupil cycle time was abnormal in all patients with PAF; sustained pupil cycling was absent in 5 of the 8 eyes tested of the PAF patients, compared with only 16 eyes from 70 control subjects. Pupil constriction in response to 2.5% methacholine, indicative of parasympathetic denervation hypersensitivity, was significantly increased in patients with PAF (p < 0.001), whilst pupil dilation in response to 0.5% phenylephrine, indicative of sympathetic denervation hypersensitivity, was also significantly higher in the PAF patients (p < 0.001). The results suggest that ocular autonomic function may provide a sensitive early indicator of generalised autonomic dysfunction. |
| |
Keywords: | autonomic neuropathy denervation hypersensitivity pupil cycle time progressive autonomic failure |
本文献已被 SpringerLink 等数据库收录! |
|