| MDM2和p53蛋白在膀胱癌中过度表达的意义 |
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| 引用本文： | 张杰,王晖,郭震华. MDM2和p53蛋白在膀胱癌中过度表达的意义[J]. 肿瘤, 2000, 20(2): 133-134 |
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| 作者姓名： | 张杰 王晖 郭震华 |
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| 作者单位： | [1]常熟市第二人民医院泌尿外科 [2]苏州医学院附属一院泌尿外科 |
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| 摘 要： | 目的 观察膀胱癌中ＭＤＭ２和ｐ５３蛋白的表达状况及意义。方法 用免疫组化检测７０例原发性膀胱移行细胞癌（ＴＣＣ）中ＭＤＭ２和ｐ５３蛋白的过度表达情况。结果 ＭＤＭ２核免疫阳笥４４．２９％（３１／７０），３２例（４５．７１％）ｐ５３核染色体阳性，两者共同阳性９例。ＭＤＭ２表达是膀胱癌的早期表现，ｐ５３蛋白与ＭＤＭ２相反，两者呈负相关。结论 ＭＤＭ２和ｐ５３蛋白是膀胱癌发生发展的两个早晚基因事件。
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| 关 键 词： | 膀胱肿瘤 基因产物 MDM2 基因表达 |
CLINICAL SIGNIFICANCE OF OVER EXPRESSION OF MDM2 AND p53 PROTEIN IN BLADDER CANCER |
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| ZHANG Jie ,WANG Hui ,GUO Zhen hua ,Urinific Surgery,Changshu Second People's Hospital,Jiangsu,,China, Urinific Surgery,The First Hospital,Suzhou Medical College,Jiangsu,,China. CLINICAL SIGNIFICANCE OF OVER EXPRESSION OF MDM2 AND p53 PROTEIN IN BLADDER CANCER[J]. Tumor, 2000, 20(2): 133-134 |
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| Authors: | ZHANG Jie WANG Hui GUO Zhen hua Urinific Surgery Changshu Second People's Hospital Jiangsu China Urinific Surgery The First Hospital Suzhou Medical College Jiangsu China |
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| Affiliation: | ZHANG Jie 1,WANG Hui 2,GUO Zhen hua 2,1Urinific Surgery,Changshu Second People's Hospital,Jiangsu,215500,China, 2Urinific Surgery,The First Hospital,Suzhou Medical College,Jiangsu,215006,China |
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| Abstract: | Objective To observe and study the expression of MDM2 and p53 proteins and its significance in bladder cancers. Methods Using immuno histo chemical method to investigate the expression of MDM2 and p53 proteins in 70 cases of primary transitional cell carcinoma (TCC) of urinary bladder. Results MDM2 showed a nucleo immuno positive rate of 44 29 % (31/70), 32 cases showed a nuclear stain positive rate of 45 71 % of p53, and 9 cases showed both positive. Expression of MDM2 was an early manifestation of bladder cancers, however, p53 protein is just on the contrary and showed a negative correlation ( r= -0 5346, 0 05> P >0 01). Conclusion MDM2 and p53 proteins are an early and a late gene events in the occurrence and progress of bladder cancers. |
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| Keywords: | Bladder neoplasma Gene products MDM2 Gene products p53 |
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