Multiple sclerosis with very late onset: a report of a case with onset at age 82 years and review of the literature |
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Authors: | Abe M Tsuchiya K Kurosa Y Nakai O Shinomiya K |
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Affiliation: | Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Kudanzaka Hospital, Japan. ABERIKAN@aol.com |
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Abstract: | This is a report of a patient with late-onset multiple sclerosis at age 82 years. The lesion involved was located on the spinal cord. Multiple sclerosis mainly affects young adults, making late onset of multiple sclerosis a rarity, particularly for cases after age 80 years. Common characteristics of late-onset multiple sclerosis reported in other publications are predominant involvement of the spinal cord and a progressively worsening course with a serious prognosis. In this case, magnetic resonance imaging revealed a large area of high signal intensity in the cervical and upper thoracic spinal cord on T2-weighted images. An increased immunoglobulin G level in cerebrospinal fluid also played a diagnostic role in ruling out cervical spondylotic myelopathy. Spontaneous improvement occurred 2 months after the onset. Unlike other patient described in the literature, the clinical course of this man was not as bleak. |
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