CONGENITAL PRIMARY HYPOTHYROIDISM AND HLA |
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| Authors: | B. BROCK JACOBSEN N. J. BRANDT A. SVEJGAARD |
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| Affiliation: | Department of Paediatrics G, Section of Clinical Genetics, and the Tissue Typing Laboratory of the Blood Grouping Department. Rigshospitalet and from the Endocrine Clinic, Children's Hospital Fuglebakken, Copenhagen, Denmark |
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| Abstract: | ABSTRACT. Previous studies have suggested an association between congenital hypothyroidism and HLA-Aw24 or B18 antigens. The frequencies of HLA-A, B and C antigens were studied in 33 unrelated Danish patients with congenital hypothyroidism (5 with aplasia of the thyroid gland, 16 with ectopic thyroids and 8 with thyroid hyshormonogenesis). HLA-Aw24 only appeared in patients with ectopic thyroids and HLA-B18 was only seen in patients with dyshormonogenesis. However, the frequencies of HLA antigens in patients and in a large number of controls did not differ statistilly significantly. We conclude that HLA typing is without any predictive value in determining the risk of developing or giving birth to a child with congenital hypothyroidism. |
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| Keywords: | Congenital hypothyroidism HLA-A B and C antigens |
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