| 三七总皂苷对栀子提取物中栀子苷大鼠肠吸收的影响 |
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| 引用本文： | 翟永松,杜守颖,陆洋,王玥,徐冰,高瑛.三七总皂苷对栀子提取物中栀子苷大鼠肠吸收的影响[J].中华中医药杂志,2010(3). |
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| 作者姓名： | 翟永松 杜守颖 陆洋 王玥 徐冰 高瑛 |
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| 作者单位： | 北京中医药大学中药学院; |
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| 基金项目： | “重大新药创制”科技重大专项(No.2009ZX09502-008)~~ |
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| 摘 要： | 目的:研究益智方中三七总皂苷对栀子提取物中栀子苷肠吸收的影响。方法:采用大鼠在体肠吸收模型比较单味栀子提取物组(单味组)与配伍三七总皂苷组(配伍组)在低、中、高浓度下有效成分栀子苷的肠吸收情况。结果:单味组低、中、高浓度的吸收速率常数分别为0.166h-1,0.135h-1,0.080h-1;配伍组低、中、高浓度的吸收速率常数为0.145h-1,0.112h-1,0.066h-1。结论:在一定浓度范围内,配伍组栀子苷的吸收速率常数K均小于单味组,且有显著性差异(P<0.05)。
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| 关 键 词： | 栀子提取物 三七总皂苷 栀子苷 大鼠在体肠吸收 |
Impact of notoginseng total saponin on intestinal absorption kinetics of jasminoidin |
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| ZHAI Yong-song,DU Shou-ying,LU Yang,WANG Yue,XU Bing,GAO Ying.Impact of notoginseng total saponin on intestinal absorption kinetics of jasminoidin[J].China Journal of Traditional Chinese Medicine and Pharmacy,2010(3). |
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| Authors: | ZHAI Yong-song DU Shou-ying LU Yang WANG Yue XU Bing GAO Ying |
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| Institution: | Chinese Herbal Pharmaceutics Department of Chinese Pharmacy School;Beijing University of Chinese Medicine;Beijing 100102;China |
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| Abstract: | Objective:To investigate the impact of notoginseng total saponin on intestinal absorption kinetics of jasminoidin.Methods:Rat intestinal absorption in vitro experiment was used to compare the intestinal absorption of jasminoidin extracted from sigle garcenia and combination of gardenia and notoginseng total saponin at high,middle and low dosages.Results:The intestinal absorption of jasminoidin extracted from sigle garcenia at high,middle and low dosages were 0.166 h-1,0.135 h-1,0.080 h-1 respectively.And th... |
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| Keywords: | Gardenia extract Notoginseng total saponin Jasminoidin Intestinal obsorption in vitro |
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