Effect of benzodiazepines on synaptosomal Ca2+ transport in mice with different phenotype of emotional stress reactions

The effects of 5 benzodiazepines on basal and K⁺-induced Ca²⁺ concentration in synaptoneurosomes from intact and stressed C57B1/6 and BALB/c mice were studiedin vitro. Membrane depolarization induced by low KCl concentrations produced different effects on Ca²⁺ accumulation by synaptoneurosomes from two mouse strains. Benzodiazepines appliedin vitro exerted no effects on Ca²⁺ influx. In synaptoneurosomes from both C57B1/6 and BALB/c mice exposed to emotional stress diazepam in a dose of 5 mg/kg reduced the basal and K⁺-induced Ca²⁺ accumulation. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 3, pp. 304–305, March, 2000