| 微量内毒素促平滑肌细胞增殖作用的实验观察 |
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| 引用本文： | 姜志胜,杨永宗,周元芳,贺朝霞,刘安元.微量内毒素促平滑肌细胞增殖作用的实验观察[J].南华大学学报(医学版),1996(1). |
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| 作者姓名： | 姜志胜 杨永宗 周元芳 贺朝霞 刘安元 |
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| 作者单位： | 衡阳医学院心血管病研究所 |
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| 摘 要： | 本文观察了微量内毒素对动脉壁平滑肌细胞的促增殖作用及硝苯吡啶对这一作用的影响。结果发现：在一定范围内，内毒素具浓度依赖性促平滑肌细胞增殖作用，且以培养液中浓度为１０－７ｇ／ｍｌ作用最强。硝苯吡啶可显著抑制内毒素的这一作用。提示（１）内毒素通过促进平滑肌细胞的增殖而与动脉粥样硬化的形成密切相关；（２）内毒素的促平滑肌细胞增殖作用与细胞内外Ｃａ２＋的跨膜运转有关。
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| 关 键 词： | 内毒素 平滑肌细胞 促增殖作用 硝苯吡啶 |
The Experimental Observation of Smooth Muscle Cells Proliferation Stimulated by Endotoxin |
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| JiangZhisheng,YangYongzong,ZhouYuanfang,et al.The Experimental Observation of Smooth Muscle Cells Proliferation Stimulated by Endotoxin[J].Journal of Nanhua University(Medical Edition),1996(1). |
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| Authors: | JiangZhisheng YangYongzong ZhouYuanfang |
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| Abstract: | The effect of endotoxin-stimulated proliferation on porcine aorta smooth muscle cells(SMC) was investigated.The results show that a low level of endotoxin can accelerate SMC proliferation with a dose dependent relationship to a certain degree(The most significant effect appears when endotoxin concentration in medium is 107g/ml).and nifedipine exerts an inhibitory influence on this multiplication.We hereby conclude that:(1)endotoxin may associate with the formation and development of atherosclerosis by stimulating SMC multiplication;(2) the endotoxin -accelerated proliferation of SMC is relevant to Ca2-trans-memberane transferation. |
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| Keywords: | endotoxin smooth muscle cells proliferation atherosclerosis |
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