急性冠状动脉综合征患者脂肪酸结合蛋白的测定价值

目的探讨急性冠状动脉综合征(ACS)患者血清脂肪酸结合蛋白(FABP)的变化及其测定意义。方法选择74例ACS患者和40名正常对照组,采用双抗体夹心酶联一步法测定血清FABP,同时以固相层析免疫法对心肌肌钙蛋白-I(cTn-I)进行定性测定。结果在急性心肌梗死(AMI)组患者中,FABP测定值及阳性率、cTn-I阳性率均高于正常对照组及不稳定型心绞痛(UA)组(P<0.05);在UA组中,FABP测定值及阳性率与正常对照组之间差异有统计学意义(P<0.05),而cTn-I阳性率差异无统计学意义;同时UA组中FABP阳性率要高于cTn-I(P<0.05)。结论FABP对ACS早期诊断、指导治疗及预后有重要意义。

The value of determining the fatty acid-binding protein levels to acute coronary syndrome

Objective To study the change of fatty acid-binding protein(FABP) levels in acute coronary syndrome(ACS) and the clinical value.Methods Seventy-four cases of ACS,40 cases of controllers were selected.The serum level of FABP was measured by enzyme-linked immunosorbent assay(ELISA).The cardiac troponin-I(cTn-I) was measured by qualitative analysis.Results In acute myocardial infarction(AMI) group,the measurements and positive rate of FABP,the positive rate of cTn-I were significantly higher than those in control group and unstable angina(UA) group (P<0.05).There were significant differences in measurements and positive rate of FABP between UA group and control group (P<0.05), but no difference in the positive rate of cTn-I existed between UA group and control group.In UA group,the positive rate of FABP was significantly higher than that of cTn-I.Conclusion The level of FABP has important significance in the early diagnosis,treatment and prognosis.