鹿根的化学成分

目的研究鹿根(Rhaponticum carthamoides(Willd.)Iljin.)中化学成分。方法采用反复硅胶柱色谱法、Sephadex LH-20柱色谱法、ODS柱色谱法和反复重结晶等进行分离纯化,并通过理化常数测定和波谱分析鉴定了其化学结构。结果从鹿根体积分数为70%的乙醇溶液提取物中分离得到9个化合物,并鉴定其结构为:肉桂酸(cinnamic acid,1)、对羟基苯甲酸(4-hydroxybenzoic acid,2)、3,4-二羟基苯甲酸(3,4-dihydroxybenzoic acid,3)、3-羟基-4-甲氧基苯甲酸(3-hydroxy-4-methoxylbenzoic acid,4)、2,4-二羟基苯甲酸(2,4-dihydroxybenzoic acid,5)、苯甲醇-O-β-D-吡喃葡萄糖苷(benzyl-O-β-D-glucopyranoside,6)、丁香苷(syringin,7)、β-谷甾醇(β-sitosterol,8)、胡萝卜苷(daucosterol,9)。结论化合物1、4、5、6均为首次从漏芦属植物中分离得到,化合物7为首次从本植物中分离得到。

Constituents from root of Rhaponticum carthamoides(Willd.)Iljin.

Objective To study the chemical constituents from the herb Rhaponticum carthamoides (Willd.) Iljin. Methods The compounds were isolated by chromatography on silica gel column, Sephadex LH-20 column, ODS column and recrystallizing method, identified on the basis of physico-chemical constants and spectral analysis. Results 9 compounds were isolated and elucidated as cinnamic acid (1), 4-hydroxybenzoic acid (2), 3,4-dihydroxybenzoic acid (3), 3-hydroxy-4-methoxylbenzoic acid (4), 2,4-dihydroxybenzoic acid (5), benzyl-O-β-D-glucopyran -oside (6), syringin (7), β-sitosterol (8), daucosterol (9). Conclusion Compound 1, 4, 5, 6 are obtained from this genus for the first time, and compound 7 is isolated from this herb firstly.