影响早期胃癌淋巴结转移的多因素分析

目的探讨早期胃癌患者淋巴结转移的临床病理因素。方法回顾性分析1999年1月至2008年6月间行D2手术的369例早期胃癌患者的病例资料，对其年龄、性别、肿瘤位置、肿瘤大小、浸润深度、脉管瘤栓、肿瘤大体类型和分化程度与淋巴结转移的关系进行Logistic回归多因素分析。结果影响早期胃癌淋巴结转移的主要因素有患者的性别、肿瘤大小、浸润深度、脉管瘤栓和肿瘤分化类型，其中肿瘤大小和浸润深度是主要的独立危险因素（P〈0.01）。结论对早期胃癌患者，手术方案的选择需综合患者肿瘤大小、浸润深度、脉管瘤栓、分化程度和性别等因素来制定。

Multivariate analysis of risk factors of lymph node metastasis in early gastric cancer

Objective To investigate the clinicopathological factors affecting lymph node metastasis in early gastric cancer (EGC). Methods Clinicopathological data of 369 patients with EGC from Jan. 1999 to Jun. 2008 were analyzed retrospectively. Multivariate analysis was performed to find the risk factors affecting lymph node metastasis. Results The age, gender, tumor size, invasion depth, histological classification and vascular cancer thrombosis were associated with lymph node metastasis. Multivariate analysis showed that tumor size and depth of invasion were main independent risk factors. Conclusions The main independent risk factors affecting lymph node metastasis in EGC are tumor size and invasion depth. The gender, vascular cancer thrombosis, tumor size, invasion depth and histological classification should be considered to establish the surgical program.