Inhibition of concanavalin A-induced mice hepatitis by coumarin derivatives |
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Authors: | Okamoto T Yoshida S Kobayashi T Okabe S |
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Affiliation: | Research Laboratories, Nippon Chemiphar Co., Ltd., Misato, Saitama, Japan. ncokamot@green.ocn.ne.jp |
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Abstract: | The effects of coumarin derivatives, osthole, imperatorin, Pd-Ia, Pd-II and Pd-III, on mice concanavalin A (Con A) (0.2 mg/mouse, i.v.)-induced hepatitis were studied. At the dose of 200 mg/kg (i.p.), these coumarins inhibited more than 90% of the Con A-induced elevation of plasma alanine aminotransferase activity, but glycyrrhizin (200 mg/kg, i.p.) caused only 45% inhibition. At the dose of 100 mg/kg (i.p.), osthole produced the strongest inhibition among these coumarins. The inhibitory activity of osthole is lost when its 7-methoxy group is replaced by a 7-hydroxy group to form osthenol. The present results showed that coumarin derivatives inhibited Con A-induced hepatitis, with osthole being the most inhibitory. |
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